Transcription Factor
| Accessions: | UP00623A (UniPROBE 20160601) |
| Names: | DRES93, VAX2_REF, ventral anterior homeobox 2 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | ventral anterior homeobox 2: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. |
| Length: | 90 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 TIREIVLPKGLDLDRPKRTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQV 60 61 KVWFQNRRTKQKKDQSRDLEKRASSSASEA |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1ig7_A, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 3d1n_M, 1nk2_P, 1fjl_B, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 1zq3_P, 1b72_A, 5hod_A, 3l1p_A, 2ld5_A, 3a01_E, 7q3o_C, 5jlw_D, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1au7_A, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1o4x_A, 4qtr_D, 1le8_B, 1du0_A, 1mnm_C, 1puf_B, 1k61_B, 8g87_X |
| Binding Motifs: | UP00623A_1 tyatcggsTAATTAscycAktmr UP00623A_2 wtakcggsYAATTRscymAdwar |
| Binding Sites: | GGTAATTA ACTAATTA AGTAATTA ATAATTAC ATTAATTA CATAATTA CCTAATTA CCTCATTA CTAATGAG CTAATTAA CTAATTAC CTAATTAG CTCATTAA CTTAATTA GATAATTA GCTAATTA GTAATTAA GTAATTAC GTCATTAA GTTAATGA GTTAATTA TAATTAAA TAATTAGA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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