Transcription Factor
| Accessions: | T028093_1.02 (CISBP 1.02), UP00316A (UniPROBE 20160601), Q03935 (JASPAR 2024) |
| Names: | T028093_1.02;, YAP6, AP-1-like transcription factor YAP6, HAL7, YD9320A.09C, YD9320A.10C, YDR259C, YAP6_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance |
| Notes: | experiment type:PBM, family:bZIP |
| Length: | 383 |
| Pfam Domains: | 220-277 bZIP transcription factor |
| Sequence: (in bold interface residues) | 1 MQNPPLIRPDMYNQGSSSMATYNASEKNLNEHPSPQIAQPSTSQKLPYRINPTTTNGDTD 60 61 ISVNSNPIQPPLPNLMHLSGPSDYRSMHQSPIHPSYIIPPHSNERKQSASYNRPQNAHVS 120 121 IQPSVVFPPKSYSISYAPYQINPPLPNGLPNQSISLNKEYIAEEQLSTLPSRNTSVTTAP 180 181 PSFQNSADTAKNSADNNDNNDNVTKPVPDKDTQLISSSGKTLRNTRRAAQNRTAQKAFRQ 240 241 RKEKYIKNLEQKSKIFDDLLAENNNFKSLNDSLRNDNNILIAQHEAIRNAITMLRSEYDV 300 301 LCNENNMLKNENSIIKNEHNMSRNENENLKLENKRFHAEYIRMIEDIENTKRKEQEQRDE 360 361 IEQLKKKIRSLEEIVGRHSDSAT |
| Interface Residues: | 227, 230, 231, 232, 234, 235, 238, 239 |
| 3D-footprint Homologues: | 1gd2_G |
| Binding Motifs: | MA0418.1 sgkywgmTTAyGTaAkcrrc UP00316A_1 sgkywgmTTAyGTaAkcrrc M0351_1.02 gakkrgGWRAy MA0418.2 gmTTAyGTaA |
| Binding Sites: | AAAGAAAG AAGAGGGG AAGGGGGA ACGTAATC AGGGGGAG ATTTCTTC ATTTTTTC CCTCCCCC CTCCCCCC GAAAAAAA GAGGGGGA GGGGGAAA GGGGGAGA TCCCCCAA TGAAAAAA TTACATAA TTACGTAA ATTTCAAA CCCCCTTC GAAAAAGA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Newburger D.E, Bulyk M.L. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic acids research 37:D77-82 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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