Transcription Factor
| Accessions: | UP00624A (UniPROBE 20160601) |
| Names: | homeobox protein VENTX, HPX42B, MGC119910, MGC119911, NA88A, VENT homeobox homolog, VENT-like homeobox protein 2, VENTX_REF, VENTX2 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein VENTX: This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008] |
| Length: | 85 |
| Pfam Domains: | 15-70 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTW 60 61 FQNRRMKHKRQMQDPQLHSPFSGSL |
| Interface Residues: | 12, 13, 15, 16, 17, 55, 56, 58, 59, 62, 63, 66, 67, 70 |
| 3D-footprint Homologues: | 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 1jgg_B, 3rkq_B, 6es3_K, 7q3o_C, 1b72_A, 4xrs_G, 2ld5_A, 1ig7_A, 5zfz_A, 4j19_B, 3a01_E, 2h1k_B, 5flv_I, 1puf_A, 5zjt_E, 3cmy_A, 2hdd_A, 7psx_B, 5hod_A, 2r5y_A, 1puf_B, 6a8r_A, 1au7_A, 2hos_A, 1fjl_B, 5jlw_D, 4cyc_A, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 3l1p_A, 1o4x_A, 1le8_B, 1du0_A, 8g87_X, 4qtr_D, 1mnm_C, 1k61_B, 4xrm_B |
| Binding Motifs: | UP00624A_1 wwmdwkgbTAATTAkcmawwawa |
| Binding Sites: | GGTAATTA AATTAGCG ACCAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAT ATTAATTA CAATTAGC CATAATTA CGTAATTA CTAATTAC CTAATTAG GATAATTA GCTAATTA GTAATTAC GTTAATTA AATCGATT CCAATTAC CCCATTAC |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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