Transcription Factor
| Accessions: | Uncx_DBD (HumanTF 1.0), UP00142A (UniPROBE 20160601) |
| Names: | Homeobox protein unc-4 homolog, Homeobox protein Uncx4.1, UNC4_MOUSE, Uncx, Not Available, Unc4.1 homeobox (C. elegans), Uncx4.1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q78DU3 |
| Description: | Unc4.1 homeobox (C. elegans) |
| Notes: | Ensembl ID: ENSMUSG00000029546; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 LADSGDPDKESPGCKRRRTRTNFTGWQLEELEKAFNESHYPDVFMREALALRLDLVESRV 60 61 QVWFQNRRAKWRKKENTKKGPGRPAHNSHPTTC |
| Interface Residues: | 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 4j19_B, 1ig7_A, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 5zfz_A, 1fjl_B, 2h1k_B, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 6m3d_C, 3l1p_A, 2ld5_A, 7psx_B, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 2hos_A, 1au7_A, 4cyc_A, 5flv_I, 1b72_A, 3a01_E, 1e3o_C, 7xrc_C, 2xsd_C, 1du0_A, 4qtr_D, 1o4x_A, 8g87_X, 5zjt_E |
| Binding Motifs: | UP00142A_1 vataaTTAATTAAygsg Uncx_DBD_1 yTAATytAATTAr Uncx_DBD_2 ytAATTAm |
| Binding Sites: | AATAATTA AATTAAAT AATTAATT ACTAATTA AGTAATTA ATAATTAA ATAATTAG ATCAATTA ATTAATTA CCAATTAG CCTAATTA CTAATTAA CTAATTAC CTAATTAG CTTAATTA GCTAATTA GTAATTAA GTTAATTA TAATTAAA TAATTAGA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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