Transcription Factor
| Accessions: | UP00512A (UniPROBE 20160601) |
| Names: | abx, BX-C, bx[D], bxd, bxd[D], bxl, Cbx, CG10388, Dm Ubx, Dmel\CG10388, DmUbx, DUbx, Hm, Homeotic protein ultrabithorax, l(3)89Eb, pbx, Uab, Ubx, Ubx1b, Ultrabithorax |
| Organisms: | Drosophila melanogaster |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Ultrabithorax: Ubx is a sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor. |
| Length: | 95 |
| Pfam Domains: | 23-79 Homeobox domain |
| Sequence: (in bold interface residues) | 1 KRYSESLAGSLLPDWLGTNGLRRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALC 60 61 LTERQIKIWFQNRRMKLKKEIQAIKELNEQEKQAQ |
| Interface Residues: | 22, 23, 24, 25, 26, 27, 64, 65, 67, 68, 71, 72, 75, 76, 79 |
| 3D-footprint Homologues: | 4j19_B, 3a01_E, 1puf_A, 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 6a8r_A, 3cmy_A, 3d1n_M, 1nk2_P, 1zq3_P, 6m3d_C, 1jgg_B, 3lnq_A, 2lkx_A, 1au7_A, 2ld5_A, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 5flv_I, 5zjt_E, 7psx_B, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 3l1p_A, 1o4x_A, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00512A_1 aawraarGGTAATTAmydkwkw |
| Binding Sites: | GGTAATTA AATAATTA ACTAATTA AGTAATTA ATAATTAC ATAATTAT ATTAATTA CATAATTA CATTAATG CCCATTAA CTAATTAG CTTAATTA GATAATTA GCAATTAA GTAATTAA GTAATTAC GTCATTAA GTTAATTA TAATTACA TTAATTAA |
| Publications: | Busser BW, Shokri L, Jaeger SA, Gisselbrecht SS, Singhania A, Berger MF, Zhou B, Bulyk ML, Michelson AM. Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity. Development 139:1164-74 (2012). [Pubmed] |
| Related annotations: | PaperBLAST |
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