Transcription Factor
| Accessions: | UP00627B (UniPROBE 20160601) |
| Names: | AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT1_F392L, WT33 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | Wilms tumor protein: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. |
| Length: | 138 |
| Pfam Domains: | 17-39 C2H2-type zinc finger 31-58 Zinc-finger double domain 45-69 C2H2-type zinc finger 45-69 Zinc finger, C2H2 type 62-82 Zinc-finger double domain 75-97 C2H2-type zinc finger 75-97 Zinc finger, C2H2 type 89-115 Zinc-finger double domain 103-127 Zinc finger, C2H2 type 103-125 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 TLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSD 60 61 QLKRHQRRHTGVKPFQCKTCQRKLSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDEL 120 121 VRHHNMHQRNMTKLQLAL |
| Interface Residues: | 2, 4, 27, 28, 29, 30, 31, 33, 34, 36, 37, 40, 57, 58, 59, 60, 61, 63, 64, 68, 75, 85, 86, 87, 88, 89, 91, 92, 93, 115, 116, 117, 118, 119, 120, 121, 122, 123 |
| 3D-footprint Homologues: | 7w1m_H, 5v3j_F, 2i13_A, 6jnm_A, 7n5w_A, 3uk3_C, 5und_A, 5k5i_A, 8ssu_A, 6ml4_A, 6blw_A, 5kkq_D, 6u9q_A, 5yel_A, 5ei9_F, 2kmk_A, 8ssq_A, 2gli_A, 7eyi_G, 8h9h_G, 2lt7_A, 1tf6_A, 7y3m_I, 6e94_A, 7ysf_A, 6wmi_A, 2jpa_A, 1ubd_C, 8cuc_F, 7y3l_A, 1tf3_A, 1g2f_F, 4x9j_A, 2wbs_A, 1mey_C, 7txc_E, 5kl3_A, 2drp_D, 1f2i_J, 6a57_A, 8gn3_A, 5hso_A, 1llm_D, 5yj3_D, 4m9v_C |
| Binding Motifs: | UP00627B_1 TwtTwawATAmAwATAAwwTwkG |
| Binding Sites: | AATAAAAT ATAAATTA ATAATATA ATATTATG CCCCCCGC CCCCCGCA CCTCCCCC GCGGGGGA TTAATAAA AATTATCA AGTATATA ATAATACA ATACATAT ATATAAGA ATGTATTA CGGGGGAG CTCCCCCA GTATGATA TACATATA TACGGTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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