Transcription Factor
| Accessions: | SOX15_full (HumanTF 1.0), SOX15_TF2 (HumanTF2 1.0) |
| Names: | Protein SOX-12, Protein SOX-15, Protein SOX-20, SOX15, SOX15_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | O60248 |
| Notes: | Ensembl ID: ENSG00000129194; Full protein sequence; TF family: HMG; Clone source: hORFeome, Ensembl ID: ENSG00000129194; Construct type: TF2(3xFLAG); TF family: SOX; Clone source: Jolma et al. 2013 |
| Length: | 234 |
| Pfam Domains: | 48-110 Domain of unknown function (DUF1898) 49-117 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWS 60 61 SAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRP 120 121 RRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSS 180 181 HCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL* |
| Interface Residues: | 51, 54, 56, 57, 58, 60, 64, 75, 76, 77, 80, 118, 122 |
| 3D-footprint Homologues: | 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 1hry_A, 3tq6_B, 1ckt_A |
| Binding Motifs: | SOX15_full_1 AACAATAmCATTGTT SOX15_full_2 ATCAATAmCATTGAT SOX15_full_3 ATGAATAACATTCAT CUX1_SOX15_1 ATCrATwsayatrssywTTGtt CUX1_SOX15_2 dATCrATrammdkbrwCAAwrs CUX1_SOX15_2_3 rATCrATammcktwrawCAAwrs ETV2_SOX15_1 rcCGGAWgtrvgkbywTTGT ETV2_SOX15_2 rsCGGAAryrsbyyAtTGT ETV2_SOX15_2_3 rCCGGAWGyamrmACAAwrg ETV2_SOX15_2_3_4 aCCGGAWryvrwraACAAwrs GCM2_SOX15_1 aTrcGGGywykyyywTTGTtk GCM2_SOX15_2 aTrcGGGydwwttyyaTTGTyt GCM2_SOX15_2_3 ATRcGGGywbraaACAAwr GCM2_SOX15_2_3_4 aTRcGGGygaaaACAATr HOXB2_SOX15_1 ACAATrsmawssymaTya HOXB2_SOX15_2 ACAAwrsravsymATtA HOXB2_SOX15_2_3 ACAATrramsymATtA HOXB2_SOX15_2_3_4 symATtarsmamaCAAtr HOXB2_SOX15_2_3_4_5 stmATyasmvmvraCAATg POU2F1_SOX15_1 wtGmATaACAAwr POU2F1_SOX15_2 wtGmATrACAAwr POU2F1_SOX15_2_3 ywtGmATAACAAwrra TEAD4_SOX15_1 rACAAwrraargwATGy TEAD4_SOX15_2 rACAAtrsrrhgGaATgy |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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