DNA Binding Motif

						

			
Accessions: CUX1_SOX15_2 (HumanTF2 1.0)

			
Names: CUX1_SOX15
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 22
Consensus: dATCrATrammdkbrwCAAwrs
Weblogo: 
PSSM: P0      A      C      G      T
01     29      5     36     32      d
02    102      2      3      2      A
03      1      0      1    102      T
04      1    102      0     13      C
05     45      1     57      0      r
06    102      0      0      5      A
07     10      0      1    102      T
08     39     18     30     15      r
09     34     21     23     24      a
10     29     30     24     20      m
11     29     41     16     16      m
12     27     18     27     30      d
13     24     21     27     30      k
14     17     30     30     26      b
15    102     48     63     21      r
16    102     10      4     60      w
17      5    102      8     11      C
18    102      4     10      7      A
19    102      5      3      9      A
20     52      8      2    102      w
21     44     12     58     13      r
22     30     51     51     17      s
Type: Heterodimer
Binding TFs: CUX1_TF1 (Homeobox domain, CUT domain, Homeobox KN domain)
SOX15_TF2 (HMG (high mobility group) box, Domain of unknown function (DUF1898))
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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