DNA Binding Motif

Accessions: CUX1_SOX15_2 (HumanTF2 1.0)
Names: CUX1_SOX15
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 22
Consensus: dATCrATrammdkbrwCAAwrs
Weblogo:
PSSM: P0 A C G T
01 29 5 36 32 d
02 102 2 3 2 A
03 1 0 1 102 T
04 1 102 0 13 C
05 45 1 57 0 r
06 102 0 0 5 A
07 10 0 1 102 T
08 39 18 30 15 r
09 34 21 23 24 a
10 29 30 24 20 m
11 29 41 16 16 m
12 27 18 27 30 d
13 24 21 27 30 k
14 17 30 30 26 b
15 102 48 63 21 r
16 102 10 4 60 w
17 5 102 8 11 C
18 102 4 10 7 A
19 102 5 3 9 A
20 52 8 2 102 w
21 44 12 58 13 r
22 30 51 51 17 s
Type: Heterodimer
Binding TFs: CUX1_TF1 (Homeobox domain, CUT domain, Homeobox KN domain)
SOX15_TF2 (HMG (high mobility group) box, Domain of unknown function (DUF1898))
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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