Transcription Factor
| Accessions: | HOXD12_DBD (HumanTF 1.0), HOXD12_TF1 (HumanTF2 1.0), HOXD12 (HT-SELEX2 May2017) |
| Names: | Homeobox protein Hox-4H, Homeobox protein Hox-D12, HOXD12, HXD12_HUMAN, Epstein-Barr virus-induced protein 6, TNF receptor-associated factor 1, TRAF1_HUMAN, ENSG00000170178 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | P35452 |
| Notes: | Ensembl ID: ENSG00000170178; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis, Ensembl ID: ENSG00000170178; Construct type: TF1(SBP); TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 112 |
| Pfam Domains: | 45-101 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GPLNLNMTVQAAGVASCLRPSLPDGKRCPCSPGRPAVGGGPGEARKKRKPYTKQQIAELE 60 61 NEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVLREQALALY |
| Interface Residues: | 45, 46, 47, 48, 49, 86, 87, 89, 90, 93, 94, 97, 98, 101 |
| 3D-footprint Homologues: | 1fjl_B, 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1nk2_P, 1zq3_P, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 4cyc_A, 6m3d_C, 1b72_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 3lnq_A, 1jgg_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 3l1p_A, 7xrc_C, 2xsd_C, 1le8_A, 1e3o_C, 1au7_A, 5flv_I, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1k61_B |
| Binding Motifs: | HOXD12_DBD_1 gYaATAAAA HOXD12_DBD_2 rgTCGTAAAAm HOXD12_ELK1_1 rrsCGGAAGTyGTAAAa HOXD12_ELK1_2 rsCGGAAGTmrTAAAA HOXD12_ELK3_1 kTTwAykRCCGGAAgtd HOXD12_ELK3_2 avCGGAAGTrrTwAAr HOXD12_ELK3_2_3 ksCGGAAGThRTwAwa HOXD12_EOMES_1 agGyGyGAmrmwamatTmACACCTCrTaAa HOXD12_EOMES_2 tTwAYGAkswwCmTCGTwAA HOXD12_EOMES_2_3 TmrCACcTCrTwAA HOXD12_ETV1_1 rcCGGAAGTAATAAAm HOXD12_ETV1_2 rsCGGAAGTCRTAAAw HOXD12_ETV4_1 rCCGGAAGTaATAAAm HOXD12_ETV4_2 aCCGGAAGTCGTWAAm HOXD12_FIGLA gymrTwAaaakmCAssTGk HOXD12_HOXA3_1 yTaAtkrsYmATAAAm HOXD12_HOXA3_2 yTAAtyrssTmrTAAAm HOXD12_TBX21_1 agGTGtkArGTCGTAAA HOXD12_TBX21_2 rgGYGtkdkkcgkyktwmaCAssTmrTaAa HOXD12_TBX21_2_3 yvrCACsTCrTWAw HOXD12_2 srTCGTwAah HOXD12_methyl_1 srTCGTAAAw |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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