DNA Binding Motif

Accessions: HOXD12_ETV1_2 (HumanTF2 1.0), UN0568.1 (JASPAR 2024)
Names: HOXD12_ETV1, HOXD12::ETV1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: rsCGGAAGTCRTAAAw
Weblogo:
PSSM: P0 A C G T
01 3975 492 2321 1193 r
02 965 4245 2051 132 s
03 214 6296 64 2 C
04 16 16 6296 5 G
05 4 0 6296 10 G
06 6296 8 11 2 A
07 6296 100 0 476 A
08 166 0 6296 5 G
09 16 21 16 6296 T
10 397 4543 5 1351 C
11 2452 30 6296 24 R
12 5 0 9 6296 T
13 6296 69 10 1140 A
14 6296 5 7 43 A
15 6296 267 14 140 A
16 2207 871 1356 1862 w
Type: Heterodimer
Binding TFs: ETV1_TF2 (Ets-domain)
HOXD12_TF1 (Homeobox domain)
P50549 (Ets-domain, PEA3 subfamily ETS-domain transcription factor N terminal domain)
P50549
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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