DNA Binding Motif

						

			
Accessions: HOXD12_ETV4_2 (HumanTF2 1.0), UN0569.1 (JASPAR 2024)

			
Names: HOXD12_ETV4, HOXD12::ETV4
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: aCCGGAAGTCGTWAAm
Weblogo: 
PSSM: P0      A      C      G      T
01  21687   5083   8222   5689      a
02   3054  22994   6916    290      C
03    959  29910     45     10      C
04     30     23  29910     15      G
05     38     15  29910     30      G
06  29910     33     15     15      A
07  29910    704     15   1358      A
08   1235     49  29910      8      G
09     31     63    168  29910      T
10    737  29910      7   8595      C
11   2494     38  29910     65      G
12      8     31     31  29910      T
13  29910    156      0  10617      W
14  29910      0      8     58      A
15  29910    519     30    692      A
16  15982   7875   1847   4206      m
Type: Heterodimer
Binding TFs: ETV4_TF2 (Ets-domain)
HOXD12_TF1 (Homeobox domain)
P43268 (Ets-domain, PEA3 subfamily ETS-domain transcription factor N terminal domain)
P43268
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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