DNA Binding Motif

						

			
Accessions: HOXD12_ELK3_1 (HumanTF2 1.0), UN0567.1 (JASPAR 2024)

			
Names: HOXD12_ELK3, HOXD12::ELK3
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 17
Consensus: kTTwAykRCCGGAAgtd
Weblogo: 
PSSM: P0      A      C      G      T
01    255    169    280    363      k
02     97     67    201   1068      T
03    126     34     25   1068      T
04    456     47    156   1068      w
05   1068     30      9     15      A
06     52    470     74    597      y
07    113    120    433    401      k
08    748      3    300     16      R
09      8   1068    122      0      C
10     83   1068     94      0      C
11     27     17   1068     17      G
12      9      8   1068     13      G
13   1068      0      1     27      A
14   1068     20      0    342      A
15    228    163    840     26      g
16    117    238    134    578      t
17    295    170    280    323      d
Type: Heterodimer
Binding TFs: ELK3_TF2 (Ets-domain)
HOXD12_TF1 (Homeobox domain)
P41970 (Ets-domain)
P41970
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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