Transcription Factor
| Accessions: | UP00595C (UniPROBE 20160601) |
| Names: | HHO.C1, Homeobox protein HHO.C1, Homeobox protein Hox-2C, homeobox protein Hox-B7, Hox-2.3, HOX2, HOX2C, HOXB7_M190L |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein Hox-B7: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. |
| Length: | 90 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SNFRIYPWMRSSGTDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQI 60 61 KIWFQNRRLKWKKENKTAGPGTTGQDRAEA |
| Interface Residues: | 13, 15, 16, 17, 18, 19, 20, 21, 58, 59, 61, 62, 65, 66, 69, 70, 72, 73 |
| 3D-footprint Homologues: | 1b72_A, 1puf_A, 3a01_E, 1fjl_B, 6a8r_A, 1ig7_A, 3cmy_A, 2h1k_B, 5zfz_A, 2lkx_A, 6m3d_C, 3d1n_M, 1zq3_P, 3lnq_A, 1jgg_B, 1nk2_P, 2ld5_A, 3rkq_B, 5flv_I, 2hdd_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 7psx_B, 5hod_A, 2hos_A, 7q3o_C, 5jlw_D, 6es3_K, 4xrs_G, 1e3o_C, 1le8_A, 7xrc_C, 3l1p_A, 4qtr_D, 1o4x_A, 1du0_A |
| Binding Motifs: | UP00595C_1 TwasksyATAATTAtwGgtwkdr UP00595C_2 aakwywATaTATAyATwwhamw |
| Binding Sites: | AAATATAT AATATATT AGATATAT ATAATATA ATAATTAA ATAATTAT ATAATTGA ATATATAA ATATATTA ATATTAAT ATATTATG CATAATTA GTAATTAC TAATATTA TAATTATA TATATATA TATTAATA AATATGAT ACATATTC AGTATATA ATAATACA ATAATCAT ATAATTTA ATACATAT CAATAATA GTATATTA TACAAATA TACATATA TACTATAA TATATACA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.