DNA Binding Motif

						

			
Accessions: UP00595C_2 (UniPROBE 20160601)

			
Names: HHO.C1, Homeobox protein HHO.C1, Homeobox protein Hox-2C, homeobox protein Hox-B7, Hox-2.3, HOX2, HOX2C, HOXB7_M190L_R2
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 22
Consensus: aakwywATaTATAyATwwhamw
Weblogo: 
PSSM: P0      A      C      G      T
01   0.49   0.12   0.14   0.24      a
02   0.56   0.16   0.12   0.15      a
03   0.08   0.10   0.32   0.49      k
04   0.27   0.23   0.12   0.38      w
05   0.05   0.42   0.24   0.29      y
06   0.30   0.05   0.21   0.44      w
07   0.81   0.07   0.07   0.04      A
08   0.08   0.09   0.02   0.81      T
09   0.58   0.10   0.19   0.13      a
10   0.11   0.04   0.06   0.79      T
11   0.77   0.05   0.13   0.05      A
12   0.05   0.13   0.05   0.77      T
13   0.79   0.06   0.04   0.11      A
14   0.15   0.29   0.18   0.38      y
15   0.81   0.02   0.09   0.08      A
16   0.04   0.07   0.07   0.81      T
17   0.37   0.12   0.14   0.37      w
18   0.40   0.13   0.16   0.31      w
19   0.38   0.26   0.09   0.28      h
20   0.42   0.19   0.22   0.18      a
21   0.30   0.30   0.18   0.22      m
22   0.50   0.08   0.15   0.28      w
Binding TFs: UP00595C (Homeobox domain)
Binding Sites: AGATATAT
ATAATATA
ATAATTAA
ATAATTAT
ATATATAA
ATATATTA
ATATTAAT
ATATTATG
CATAATTA
GTAATTAC
TAATATTA
TATATATA
AGTATATA
ATAATACA
ATAATTTA
CAATAATA
GTATATTA
TACAAATA
TACATATA
TACTATAA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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