DNA Binding Site
| Accessions: | ACAGCTGG (UniPROBE 20160601), MA0668.3.10 (JASPAR 2024), MA0668.3.14 (JASPAR 2024), MA0668.3.15 (JASPAR 2024), MA1109.2.13 (JASPAR 2024), MA1472.3.3 (JASPAR 2024), MA1619.2.4 (JASPAR 2024), MA1641.2.14 (JASPAR 2024), MA2170.1.1 (JASPAR 2024), MA2295.1.12 (JASPAR 2024), MA2295.1.4 (JASPAR 2024), UN0733.1.16 (JASPAR 2024) |
| Organisms: | Mus musculus, Caenorhabditis elegans, Homo sapiens, Drosophila melanogaster |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 8 |
| Sequence: | ACAGCTGG |
| Type: | Heterodimer |
| Binding TFs: | UP00099A (Helix-loop-helix DNA-binding domain) UP00357A (Helix-loop-helix DNA-binding domain) UP00358A (Helix-loop-helix DNA-binding domain) UP00361A (Helix-loop-helix DNA-binding domain) UP00378A (Helix-loop-helix DNA-binding domain) UP00381A (Helix-loop-helix DNA-binding domain) UP00384A (Helix-loop-helix DNA-binding domain) UP00387A (Helix-loop-helix DNA-binding domain) Q13562 (Helix-loop-helix DNA-binding domain, Neuronal helix-loop-helix transcription factor ) Q9QYC3 (Helix-loop-helix DNA-binding domain) Q9QX98 (Helix-loop-helix DNA-binding domain) P13349 (Helix-loop-helix DNA-binding domain, Myogenic Basic domain, Myogenic determination factor 5) Q62414 (Helix-loop-helix DNA-binding domain, Neuronal helix-loop-helix transcription factor ) P10083 P13349 Q10574 Q11094 Q13562 Q62414 Q9QX98 Q9QYC3 |
| Binding Motifs: | UP00099A_1 ytyarCAGCTGCtvytk UP00357A_1 whyrATCAGCTGatsk UP00358A_1 wAyyAwATwTrgmm UP00361A_1 agwaaaawrwhdwr UP00378A_1 ctwwramwwwmmaw UP00381A_1 akwraTwagwaswm UP00387A_1 ksrACAGCTGTyrwrr UP00099A_2 bymwcCCcryccyrty UP00358A_2 / UP00384A_3 yvsamCACCTGTTmcrg UP00361A_2 / UP00384A_5 rrmsCAsCTGbGccmt UP00378A_2 / UP00384A_6 kktrmCAksTGkymmh UP00381A_2 / UP00384A_10 hmgamCAgcTGkymtc MA0668.3 aCAGATGG MA1109.2 aCAGATGG MA1472.3 ACAGCTGT MA1619.2 aCAGCTGt MA1641.2 aCAGCTGt MA2170.1 ACAGrTGk MA2295.1 gCAGCTGc UN0733.1 cCAGmTGg |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Fong AP, Yao Z, Zhong JW, Cao Y, Ruzzo WL, Gentleman RC, Tapscott SJ. Genetic and epigenetic determinants of neurogenesis and myogenesis. Dev Cell 22:721-35 (2012). [Pubmed] Sharma A, Moore M, Marcora E, Lee JE, Qiu Y, Samaras S, Stein R. The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein binding. Mol Cell Biol 19:704-13 (1999). [Pubmed] Lo HG, Jin RU, Sibbel G, Liu D, Karki A, Joens MS, Madison BB, Zhang B, Blanc V, Fitzpatrick JA, Davidson NO, Konieczny SF, Mills JC. A single transcription factor is sufficient to induce and maintain secretory cell architecture. Genes Dev 31:154-171 (2017). [Pubmed] Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE. Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility. Mol Cell Biol 33:3166-79 (2013). [Pubmed] Conerly ML, Yao Z, Zhong JW, Groudine M, Tapscott SJ. Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation. Dev Cell 36:375-85 (2016). [Pubmed] Portman DS, Emmons SW. The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage 127:5415-26 (Development.). [Pubmed] Nitta KR, Jolma A, Yin Y, Morgunova E, Kivioja T, Akhtar J, Hens K, Toivonen J, Deplancke B, Furlong EE, Taipale J. Conservation of transcription factor binding specificities across 600 million years of bilateria evolution. Elife : (2015). [Pubmed] |
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