Transcription Factor
| Accessions: | P13349 (JASPAR 2024) |
| Names: | bHLHc2, Class C basic helix-loop-helix protein 2, Myf-5, MYF5_HUMAN, Myogenic factor 5 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P13349 |
| Length: | 255 |
| Pfam Domains: | 1-83 Myogenic Basic domain 84-135 Helix-loop-helix DNA-binding domain 143-214 Myogenic determination factor 5 |
| Sequence: (in bold interface residues) | 1 MDVMDGCQFSPSEYFYDGSCIPSPEGEFGDEFVPRVAAFGAHKAELQGSDEDEHVRAPTG 60 61 HHQAGHCLMWACKACKRKSTTMDRRKAATMRERRRLKKVNQAFETLKRCTTTNPNQRLPK 120 121 VEILRNAIRYIESLQELLREQVENYYSLPGQSCSEPTSPTSNCSDGMPECNSPVWSRKSS 180 181 TFDSIYCPDVSNVYATDKNSLSSLDCLSNIVDRITSSEQPGLPLQDLASLSPVASTDSQP 240 241 ATPGASSSRLIYHVL |
| Interface Residues: | 85, 88, 89, 91, 92, 93, 95, 96 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 6od3_F, 1am9_A, 5i50_B, 2ypa_B, 2ql2_A, 2ql2_D, 5gnj_I |
| Binding Motifs: | MA1641.1 gvaCAGCTGtbc MA1641.2 aCAGCTGt |
| Binding Sites: | MA1641.2.1 / MA1641.2.2 MA1641.2.4 MA1641.2.10 / MA1641.2.12 / MA1641.2.16 / MA1641.2.20 / MA1641.2.5 / MA1641.2.7 MA1641.2.14 MA1641.1.3 / MA1641.1.5 MA1641.1.4 / MA1641.1.6 MA1641.1.11 MA1641.1.12 MA1641.1.13 MA1641.1.14 MA1641.1.1 / MA1641.1.3 MA1641.1.10 MA1641.1.15 MA1641.1.16 MA1641.1.15 / MA1641.1.17 MA1641.1.16 / MA1641.1.18 MA1641.1.19 MA1641.1.2 / MA1641.1.4 MA1641.1.20 MA1641.1.5 / MA1641.1.7 MA1641.1.6 / MA1641.1.8 MA1641.1.7 MA1641.1.8 MA1641.1.9 MA1641.1.1 MA1641.1.17 MA1641.1.18 MA1641.1.2 MA1641.2.11 / MA1641.2.15 / MA1641.2.19 / MA1641.2.6 / MA1641.2.8 / MA1641.2.9 MA1641.2.13 MA1641.2.17 MA1641.2.18 MA1641.2.3 |
| Publications: | Conerly ML, Yao Z, Zhong JW, Groudine M, Tapscott SJ. Distinct Activities of Myf5 and MyoD Indicate Separate Roles in Skeletal Muscle Lineage Specification and Differentiation. Dev Cell 36:375-85 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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