Transcription Factor
| Accessions: | MEIS1_DBD (HumanTF 1.0), MEIS1_TF1 (HumanTF2 1.0) |
| Names: | MEIS1, MEIS1_HUMAN, Homeobox protein Meis2, Meis1-related protein 1, MEIS2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | O00470 |
| Notes: | Ensembl ID: ENSG00000143995; DNA-binding domain sequence; TF family: homeodomain+MEIS; Clone source: Megaman, Ensembl ID: ENSG00000143995; Construct type: TF1(SBP); TF family: HomeodomainTALE; Clone source: Jolma et al. 2013 |
| Length: | 128 |
| Pfam Domains: | 49-104 Homeobox domain 65-104 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MATPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATN 60 61 IMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQG 120 121 TPYNPDGQ |
| Interface Residues: | 48, 50, 51, 95, 96, 99, 100, 101, 103, 104 |
| 3D-footprint Homologues: | 6fqp_B, 5zfz_A, 1puf_B, 4j19_B, 1le8_A, 7q3o_C, 1au7_A, 1le8_B, 8g87_X, 5hod_A, 3cmy_A, 1fjl_B, 4xrm_B, 1mnm_C, 3lnq_A, 1k61_B, 6fqq_E, 4xrs_G, 6a8r_A, 3rkq_B, 5flv_I, 2d5v_B, 6es3_K |
| Binding Motifs: | MEIS1_DBD wTGACAg HOXA13_MEIS1 dmyrTAAAaCTGTC MEIS1_DLX2 tGACArswTAATtr MEIS1_DLX3 TGACAgsyTAATtr MEIS1_DRGX_1 tGACrstaATtr MEIS1_DRGX_2 TGTCAATTA- MEIS1_ELF1 vTGmCGGAAgyr MEIS1_EOMES asgTGwkGaCAk MEIS1_EVX1 TGACAtcTAATcATTA MEIS1_HOXA13 symrTaAaacTGTCA MEIS1_HOXB13 symrTwAAmcTGTCa MEIS1_MAX wTGACrbgtsrvCACGTGc MEIS1_ONECUT2 TGACAgawAATCrATr MEIS1_SOX2 TGACAkgtkAACAATgt |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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