DNA Binding Motif

						

			
Accessions: MEIS1_SOX2 (HumanTF2 1.0)

			
Names: MEIS1_SOX2
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 17
Consensus: TGACAkgtkAACAATgt
Weblogo: 
PSSM: P0      A      C      G      T
01     17      9      8    163      T
02      5      0    163      0      G
03    163      6      0      7      A
04      0    163      5      0      C
05    163      0      2     32      A
06     14      9     59    103      k
07     38     24    108      0      g
08     15     18     28    102      t
09      0     26     46     96      k
10    163     14      0     11      A
11    163      0     19      8      A
12      0    163     24     26      C
13    163      0     19     55      A
14    163     44      5      0      A
15      0      8      2    163      T
16     35     40    163     29      g
17      2     26     40     95      t
Type: Heterodimer
Binding TFs: MEIS1_TF1 (Homeobox domain, Homeobox KN domain)
SOX2_TF1 / SOX2_TF2 (HMG (high mobility group) box, Domain of unknown function (DUF1898), SOX transcription factor)
MEIS1_Crystal (Homeobox domain, Homeobox KN domain)
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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