DNA Binding Motif

						

			
Accessions: MEIS1_DRGX_2 (HumanTF2 1.0), UN0570.1 (JASPAR 2024)

			
Names: MEIS1_DRGX, MEIS1::DRGX
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 10
Consensus: TGTCAATTA-
Weblogo: 
PSSM: P0      A      C      G      T
01   1261   5144   1955  26907      T
02   1057    349  26907    258      G
03   2903   2912    587  26907      T
04    245  26907    239    991      C
05  26907    274    115    150      A
06  26907   4282   1775   1308      A
07    723   2782   1935  26907      T
08   1485   1850   1744  26907      T
09  26907   1837   3036   6018      A
10      0      0      0      0      -
Type: Heterodimer
Binding TFs: O00470 (Homeobox domain, Homeobox KN domain)
DRGX_TF2 (Homeobox domain)
MEIS1_TF1 (Homeobox domain, Homeobox KN domain)
MEIS1_Crystal (Homeobox domain, Homeobox KN domain)
O00470
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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