DNA Binding Motif

						

			
Accessions: MEIS1_EVX1 (HumanTF2 1.0), UN0571.1 (JASPAR 2024)

			
Names: MEIS1_EVX1, MEIS1::EVX1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 16
Consensus: TGACAtcTAATcATTA
Weblogo: 
PSSM: P0      A      C      G      T
01    159     30      0   1015      T
02      0     47   1015     25      G
03   1015     26      7    198      A
04      7   1015     34     39      C
05   1015     23    120     78      A
06     58     40    229    687      t
07     81    657    233     43      c
08     12     27     19    957      T
09    858     62     75     19      A
10    912     56     17     30      A
11    222     89     67   1015      T
12    347   1015    191    199      c
13   1015     50    218     50      A
14    118     14     53   1015      T
15     40      5     99   1015      T
16   1015     69     46     58      A
Type: Heterodimer
Binding TFs: P49640 (Homeobox domain)
EVX1_TF1 / EVX1_TF2 (Homeobox domain)
MEIS1_TF1 (Homeobox domain, Homeobox KN domain)
MEIS1_Crystal (Homeobox domain, Homeobox KN domain)
P49640
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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