Transcription Factor

						

			
Accessions: MEIS1_Crystal (HumanTF2 1.0)

			
Names: Homeobox protein Meis2, MEIS1, Meis1-related protein 1, MEIS2_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: O14770
Notes: Ensembl ID: ENSG00000143995; Construct type: Crystal; TF family: Homeodomain-TALE; Clone source: Gene synthesis
Length: 63
Pfam Domains:     14-53 Homeobox KN domain
    16-53 Homeobox domain
Sequence: 
(in bold interface residues)		   1 GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMID   60
  61 QSN
Interface Residues: 44, 45, 48, 49, 50, 52, 53
3D-footprint Homologues: 4j19_B, 1le8_A, 1au7_A, 7q3o_C, 1puf_B, 8g87_X, 5hod_A, 3l1p_A, 6fqp_B, 4xrm_B, 2d5v_B, 5zfz_A, 3lnq_A, 1le8_B, 6fqq_E, 4xrs_G, 2lkx_A, 1fjl_B, 6a8r_A, 3rkq_B, 1mnm_C, 5flv_I, 3cmy_A, 1k61_B, 6es3_K
Binding Motifs: HOXA13_MEIS1 dmyrTAAAaCTGTC
MEIS1_DLX2 tGACArswTAATtr
MEIS1_DLX3 TGACAgsyTAATtr
MEIS1_DRGX_1 tGACrstaATtr
MEIS1_DRGX_2 TGTCAATTA-
MEIS1_ELF1 vTGmCGGAAgyr
MEIS1_EOMES asgTGwkGaCAk
MEIS1_EVX1 TGACAtcTAATcATTA
MEIS1_HOXA13 symrTaAaacTGTCA
MEIS1_HOXB13 symrTwAAmcTGTCa
MEIS1_MAX wTGACrbgtsrvCACGTGc
MEIS1_ONECUT2 TGACAgawAATCrATr
MEIS1_SOX2 TGACAkgtkAACAATgt
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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