DNA Binding Motif
| Accessions: | MEIS1_DBD (HumanTF 1.0), MA0498.2 (JASPAR 2024) |
| Names: | MEIS1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, JASPAR 2024 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | Site type: monomeric; SELEX cycle: 6, HT-SELEX |
| Length: | 7 |
| Consensus: | wTGACAg |
| Weblogo: |  |
| PSSM: | P0 A C G T 01 23727 18797 9714 24921 w 02 8690 5575 3174 77159 T 03 0 1249 77159 0 G 04 77159 2903 672 0 A 05 0 77159 0 1155 C 06 77159 0 9263 3861 A 07 17224 14864 29965 15106 g |
| Type: | Heterodimer |
| Binding TFs: | O00470 (Homeobox domain, Homeobox KN domain) MEIS1_DBD (Homeobox domain, Homeobox KN domain) O00470 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Knoepfler P. S., Calvo K. R., Chen H., Antonarakis S. E., Kamps M. P. Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. USA 94:14553-14558 (1997). [Pubmed] |
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