Transcription Factor
| Accessions: | Dlx1_DBD (HumanTF 1.0), UP00202A (UniPROBE 20160601) |
| Names: | Dlx1, DLX1_MOUSE, DII B, distal-less homeobox 1, Dlx-1, Homeobox protein DLX-1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q64317 |
| Description: | distal-less homeobox 1 |
| Notes: | Ensembl ID: ENSMUSG00000041911; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 VVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQV 60 61 KIWFQNKRSKFKKLMKQGGAALEGSALANGRAL |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 5zfz_A, 1ig7_A, 5zjt_E, 2h1k_B, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 5hod_A, 3lnq_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 1b72_A, 4cyc_A, 5flv_I, 3a01_E, 1jgg_B, 7psx_B, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4xrm_B, 3l1p_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00202A_1 btgarrTAATTAay Dlx1_DBD syAATTAm |
| Binding Sites: | GGTAATTA AATAATTA AATTAATT ACCAATTA ACTAATTA ATAATTAA ATAATTAC ATAATTAG ATAATTAT ATAATTGC ATTAATTA CTAATTAA CTTAATTA GATAATTA GCAATTAA GTAATTAA GTTAATTA TAATTAAA TAATTATA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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