Transcription Factor
| Accessions: | Dlx2_DBD (HumanTF 1.0), UP00126A (UniPROBE 20160601) |
| Names: | Dlx2, DLX2_MOUSE, Homeobox protein DLX-2, Homeobox protein TES-1, AW121999, DII A, distal-less homeobox 2, Dlx-2, Tes1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P40764 |
| Description: | distal-less homeobox 2 |
| Notes: | Ensembl ID: ENSMUSG00000023391; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 DLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQV 60 61 KIWFQNRRSKFKKMWKSGEIPTEQHPGASASPP |
| Interface Residues: | 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1puf_A, 1ig7_A, 5zjt_E, 3cmy_A, 6a8r_A, 3d1n_M, 1fjl_B, 5zfz_A, 2h1k_B, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 1b72_A, 5flv_I, 2hdd_A, 7psx_B, 5hod_A, 3rkq_B, 2r5y_A, 1jgg_B, 2hos_A, 5jlw_D, 4cyc_A, 1au7_A, 4xrs_G, 3a01_E, 1e3o_C, 2xsd_C, 7xrc_C, 4j19_B, 1le8_A, 8g87_X, 4qtr_D, 1mnm_C, 1du0_A, 1puf_B, 4xrm_B, 1k61_B, 3l1p_A, 1o4x_A |
| Binding Motifs: | UP00126A_1 vrdrYAATTRbhymag Dlx2_DBD syAATTAw |
| Binding Sites: | GGTAATTA AATAATTA ACCAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAC ATAATTAG ATAATTAT ATTAATTA CATAATTA CTAATTAG GATAATTA GCAATTAA GCTAATTA GTAATTAA GTAATTAC TAATTAAA TAATTATA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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