Transcription Factor
| Accessions: | Sox1_DBD (HumanTF 1.0), UP00069A (UniPROBE 20160601) |
| Names: | Sox1, SOX1_MOUSE, Sox-1, SOX-1 protein, SRY-box containing gene 1 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P53783 |
| Description: | SRY-box containing gene 1 |
| Notes: | Ensembl ID: ENSMUSG00000079994; DNA-binding domain sequence; TF family: HMG; Clone source: Hughes lab. |
| Length: | 99 |
| Pfam Domains: | 14-75 Domain of unknown function (DUF1898) 15-83 HMG (high mobility group) box 84-99 SOX transcription factor |
| Sequence: (in bold interface residues) | 1 GGGGGGGTKANQDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKVMSEAE 60 61 KRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLLKKDKY |
| Interface Residues: | 17, 20, 22, 23, 24, 26, 30, 41, 42, 43, 46, 84, 88 |
| 3D-footprint Homologues: | 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 4y60_C, 2gzk_A, 3tq6_B, 1hry_A, 1ckt_A, 7zie_A |
| Binding Motifs: | UP00069A_7 khtaATTATAATwwdm UP00069A_11 mwaAACAATTrAwhw UP00069A_1 wkwarAACAAWGraywa UP00069A_13 twyhATTGTTbtmamw UP00069A_15 wwtyaATTcAwTamdk UP00069A_9 wrkwgAACAATwrrtwt UP00069A_5 wtwrgAACAATwwwtw UP00069A_3 twATTGTTcthawh Sox1_DBD_1 aACAATaaCATTGTt Sox1_DBD_2 aTGAATwmCATTCAt Sox1_DBD_3 TCAATwmCATTGA Sox1_DBD_4 TGAATrrhyATTCA UP00069A_8 ykyasACAATrgmks UP00069A_12 gwycacATTCAtryrat UP00069A_2 arAATTGTywkrrw UP00069A_14 gkrsyraATtyrwdhm UP00069A_10 btramTGwmATtysr UP00069A_16 myaTaATTGTTakys UP00069A_4 mmwyasACAAAGrawt UP00069A_6 rtrytGGgtGGGwawwt |
| Binding Sites: | AAACAAAG AAACAATT AACAAAGA AACAATAA AACAATAG AACAATTG AAGACAAT AATTGTTC ACAAAGAA ACAAAGGA ACAACAAT ACAATTGT AGAACAAT AGACAATA ATTGTTCA CATTGTTC CTTTGTTC GAACAATA GACAAAGA ATTGTCTC |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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