DNA Binding Motif

						

			
Accessions: Sox1_DBD_1 (HumanTF 1.0), MA0870.1 (JASPAR 2024)

			
Names: Sox1
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4; Possible binding to single stranded DNA, HT-SELEX
Length: 15
Consensus: aACAATaaCATTGTt
Weblogo: 
PSSM: P0      A      C      G      T
01   1369    396    356    195      a
02   2316     51     36     85      A
03      0   2316      0      0      C
04   2316     12      0      7      A
05   2316    325      0      0      A
06     13      0      0   2316      T
07   1682      5    359    634      a
08    782    508    525    502      a
09      4   2316     51     33      C
10   2316      0      0      0      A
11      0      0    244   2316      T
12      0     14      0   2316      T
13      0      0   2316      0      G
14     79    260     58   2316      T
15    222    329    265   1499      t
Type: Heterodimer
Binding TFs: Sox1_DBD (HMG (high mobility group) box, Domain of unknown function (DUF1898), SOX transcription factor)
P53783 (HMG (high mobility group) box, Domain of unknown function (DUF1898), SOX transcription factor)
P53783
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Harley VR, Clarkson MJ, Argentaro A. The molecular action and regulation of the testis-determining factors, SRY (sex-determining region on the Y chromosome) and SOX9 [SRY-related high-mobility group (HMG) box 9]. Endocr Rev 24:466-87 (2003). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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