Transcription Factor
| Accessions: | UP00616E (UniPROBE 20160601) |
| Names: | Brain-4, Brain-specific homeobox/POU domain protein 4, Brn-4, BRN4, class 3, DFN3, DFNX2, Oct-9, Octamer-binding protein 9, Octamer-binding transcription factor 9, OTF-9, OTF9, POU domain, POU3F4_V322M, transcription factor 4 |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | POU domain, class 3, transcription factor 4: This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012] |
| Length: | 191 |
| Pfam Domains: | 17-90 Pou domain - N-terminal to homeobox domain 109-165 Homeobox domain |
| Sequence: (in bold interface residues) | 1 DHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQT 60 61 TICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVK 120 121 GVLETHFLKCPKPAAQEISSLADSLQLEKEVMRVWFCNRRQKEKRMTPPGDQQPHEVYSH 180 181 TVKTDTSCHDL |
| Interface Residues: | 42, 58, 59, 60, 61, 63, 64, 70, 74, 109, 110, 111, 112, 150, 153, 154, 157, 158, 161, 162, 165 |
| 3D-footprint Homologues: | 7u0g_M, 3d1n_M, 3l1p_A, 1o4x_A, 1e3o_C, 7xrc_C, 2xsd_C, 1au7_A, 8g87_X, 3cmy_A, 6a8r_A, 1fjl_B, 5zfz_A, 2h1k_B, 1ig7_A, 1nk2_P, 2lkx_A, 1jgg_B, 1zq3_P, 3a01_E, 5hod_A, 4xrs_G, 5jlw_D, 7q3o_C, 1le8_A, 5flv_I, 1b72_A, 5zjt_E, 3lnq_A, 3rkq_B, 2r5y_A, 6es3_K, 1mnm_C |
| Binding Motifs: | UP00616E_1 kgmcgyyyTAATTArwcakcrg |
| Binding Sites: | ACCAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAC ATAATTAG ATTAATTA CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTAATTAG CTTAATTA GATAATTA GCTAATTA GTAATTAA GTTAATTA TAATTAAA TAATTATA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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