Transcription Factor
| Accessions: | HOXA3_TF1 (HumanTF2 1.0), HOXA3_TF2 (HumanTF2 1.0) |
| Names: | Homeobox protein Hox-1E, Homeobox protein Hox-A3, HOXA3, HXA3_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF2 1.0 1 1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | O43365 |
| Notes: | Ensembl ID: ENSG00000105997; Construct type: TF1(SBP); TF family: Homeodomain; Clone source: Megaman, Ensembl ID: ENSG00000105997; Construct type: TF2(3xFLAG); TF family: Homeodomain; Clone source: Megaman |
| Length: | 145 |
| Pfam Domains: | 59-115 Homeobox domain |
| Sequence: (in bold interface residues) | 1 NPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCAGDKSPPGQASSKR 60 61 ARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKGK 120 121 GMLTSSGGQSPSRSPVPPGAGGYLN |
| Interface Residues: | 59, 60, 61, 62, 100, 101, 103, 104, 107, 108, 111, 112, 115 |
| 3D-footprint Homologues: | 3cmy_A, 5zfz_A, 1fjl_B, 6a8r_A, 2h1k_B, 1puf_A, 6m3d_C, 3d1n_M, 1nk2_P, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 2ld5_A, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4cyc_A, 1ig7_A, 7psx_B, 5hod_A, 3a01_E, 7q3o_C, 5jlw_D, 1e3o_C, 1le8_A, 7xrc_C, 1au7_A, 2xsd_C, 1puf_B, 3l1p_A, 1o4x_A, 1du0_A, 4qtr_D |
| Binding Motifs: | ELK1_HOXA3_1 aCCGGwAAtkrkwyywcycATTAc ELK1_HOXA3_2 rcCGGwAAtkr- ERF_HOXA3 asCGGAwryrrargymaTTA HOXA3 rsTMATTAas HOXA3_EOMES TAAyGagGTGtka HOXA3_PAX5 tcATTAGTCACGCwTsrcTr HOXD12_HOXA3_1 yTaAtkrsYmATAAAm HOXD12_HOXA3_2 yTAAtyrssTmrTAAAm PITX1_HOXA3 taATkrgkgkgGATTA TEAD4_HOXA3_1 rCATwCyrwasymATTA TEAD4_HOXA3_2 rCATwCCrmmcymATTA |
| Publications: | Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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