Transcription Factor
| Accessions: | UP00139A (UniPROBE 20160601) |
| Names: | Homeobox protein SAX-1, locus 2 (Drosophila), NK1 transcription factor related, NK1 transcription factor-related protein 2, Nkx-1.1, Nkx-1.2, Nkx1-2, Nkx1.1, Sax1 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P42580 |
| Description: | NK1 transcription factor related, locus 2 (Drosophila) |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SPRPRRRRAESSCAKPRRARTAFTYEQLVALENKFRATRYLSVCERLNLALSLSLTETQV 60 61 KIWFQNRRTKWKKQNPGADGAVQAGGGAPQPGT |
| Interface Residues: | 17, 18, 19, 20, 22, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1ig7_A, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 3d1n_M, 1fjl_B, 3lnq_A, 2lkx_A, 1jgg_B, 1mnm_C, 6m3d_C, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 1b72_A, 5hod_A, 3l1p_A, 3a01_E, 5jlw_D, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1au7_A, 5flv_I, 2hos_A, 5zjt_E, 4cyc_A, 7psx_B, 7xrc_C, 1e3o_C, 2xsd_C, 1le8_A, 1o4x_A, 4qtr_D, 1le8_B, 1du0_A, 1puf_B, 1k61_B, 8g87_X |
| Binding Motifs: | UP00139A_1 dtbcryYAATTRrtrcw |
| Binding Sites: | GGTAATTA AATAATTA ACCAATTA ACTAATTA AGTAATTA ATAATTAC ATAATTAG ATTAATTA CCAATTAG CCTAATTA CTAATTAA CTAATTAC CTAATTGC CTTAATTA GATAATTA GCAATTAA GCTAATTA GTAATTAC GTTAATTA TTAATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.