Transcription Factor
| Accessions: | En2_DBD (HumanTF 1.0), UP00163A (UniPROBE 20160601) |
| Names: | En2, HME2_MOUSE, Homeobox protein en-2, Homeobox protein engrailed-2, Mo-En-2, BB131122, En-2, engrailed 2 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P09066 |
| Description: | engrailed 2 |
| Notes: | Ensembl ID: ENSMUSG00000039095; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain 74-93 Engrailed homeobox C-terminal signature domain |
| Sequence: (in bold interface residues) | 1 GPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQI 60 61 KIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNH |
| Interface Residues: | 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 3d1n_M, 1ig7_A, 5zfz_A, 6fqp_B, 1puf_A, 5zjt_E, 2h1k_B, 6a8r_A, 3cmy_A, 1nk2_P, 1fjl_B, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 1zq3_P, 2ld5_A, 1b72_A, 4xrs_G, 2hos_A, 7psx_B, 4cyc_A, 2d5v_B, 5flv_I, 7q3o_C, 3a01_E, 5hod_A, 1puf_B, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 6es3_K, 2xsd_C, 1e3o_C, 7xrc_C, 1au7_A, 1le8_A, 1o4x_A, 1le8_B, 1du0_A, 3l1p_A, 4qtr_D, 1mnm_C, 6fqq_E, 1k61_B, 4xrm_B, 8g87_X |
| Binding Motifs: | UP00163A_1 wgmmyYAATTRrygrah En2_DBD ssTAATTAgb |
| Binding Sites: | GGTAATTA AATAATTA AATTAATT ACCAATTA ACTAATTA AGTAATTA ATAATTAG ATTAATTA ATTAATTG CCAATTAA CCAATTAG CCTAATTA CTAATTAA CTTAATTA GATAATTA GCTAATTA GTAATTAA GTTAATTA TAATTAGA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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