Transcription Factor
| Accessions: | Bhlhb2_DBD (HumanTF 1.0), UP00050A (UniPROBE 20160601) |
| Names: | BHE40_MOUSE, Bhlhb2, bHLHe40, Class B basic helix-loop-helix protein 2, Class E basic helix-loop-helix protein 40, E47 interaction protein 1, EIP1, Stimulated by retinoic acid gene 13 protein, basic helix-loop-helix domain containing, C130042M06Rik, class B2, Clast5, CR8, cytokine response gene 8, Dec1, eip1 (E47 interaction protein 1), eipl, Sharp2, Stimulated with retinoic acid 13, Stra13, Stra14 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | O35185 |
| Description: | basic helix-loop-helix domain containing, class B2: Mus musculus basic helix-loop-helix domain containing, class B2 |
| Notes: | Ensembl ID: ENSMUSG00000030103; DNA-binding domain sequence; TF family: bHLH; Clone source: Hughes lab. |
| Length: | 91 |
| Pfam Domains: | 20-70 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 KSRRGIKRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVL 60 61 ELTLKHVKALTNLIDQQQQKIIALQSGLQAG |
| Interface Residues: | 16, 19, 20, 21, 23, 24, 27, 28, 54 |
| 3D-footprint Homologues: | 4zpr_B, 1an4_A, 7rcu_E, 5nj8_D, 4h10_A, 6g1l_A, 5eyo_A, 1a0a_B, 7ssa_L, 7d8t_A, 5i50_B, 1am9_A, 5v0l_A, 4zpk_A, 7f2f_B, 7xi3_A, 8osl_P, 4h10_B, 8osl_O, 7xhv_B, 5nj8_C, 5sy7_B, 7xi3_B, 5v0l_B |
| Binding Motifs: | UP00050A_1 rrawkrgTCACGTGAsymrywy Bhlhb2_DBD rkCACGTGmc UP00050A_2 ygysryTmCACGTGGArrsmrgt |
| Binding Sites: | AACACGTG ACACGTGA ACACGTGC AGCACGTG ATCACGTG CACACGTG CACGCGAC CACGTGAA CACGTGAC CACGTGAG CACGTGCA CACGTGCC CACGTGCG CACGTGGA CACGTGTA CACGTGTC CCACGTGA CCACGTGC GCACGTGC TCACGTGA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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