Transcription Factor
| Accessions: | UP00383A (UniPROBE 20160601) |
| Names: | hlh-24, REF-1 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q22069 |
| Description: | REgulator of Fusion: ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1 |
| Length: | 366 |
| Pfam Domains: | 16-62 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 VLISTPPPAYAHNRKTSQEKKRRDEINAKIKELQLLIQNESDNEKMTQGDVLNRAVEVVS 60 61 RMETESPGPSSNPNRKGFFDGFRSIESLTYSFIKSLGVNSDVCQDFVQRAKQFFDRERSS 120 121 LLSTVSGKSKRRSESEILHSSMSYRSQSSSPSTSESGITIDRKEVKKNREQDRRDRQGEA 180 181 FDALKNFIIENKLMTSHQVEKMQRLNTLDIIIAYIQNKKHNFVSRSDQEQSLYAHAIAEG 240 241 KKTAKNIAFQFFKGDRHLVVRCADLEKFFEFSLSPKPLFGFPSMPIPIPPPSFPIFPFRP 300 301 FPFFPMPMAPMATSPKSQQSPSYSLDSPPPSSDTSSSSIETPSTPNENSNSNPKASRKSK 360 361 LFRPWE |
| Interface Residues: | 12, 13, 15, 19, 22, 23, 46, 163, 167, 169, 170, 173 |
| 3D-footprint Homologues: | 7f2f_B, 4h10_A, 8osl_O, 4h10_B, 8osl_P, 6g1l_A, 1an4_A, 7d8t_A, 7xhv_B, 7xi3_B, 7z5k_B |
| Binding Motifs: | UP00383A_1 wmawgGCACGTGycwwa |
| Binding Sites: | AAAAAATA AAATAAAA AACACGTG ACACGTGC ACACGTGG ACACGTGT ACCACGTG AGCACGTG CACACGTG CACGTGCA CACGTGCC CACGTGCG CACGTGGA CACGTGGC CACGTGTA CACGTGTC CCACGTGC CCACGTGG GCACGTGC ATAAAAAT |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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