Transcription Factor
| Accessions: | UP00382A (UniPROBE 20160601) |
| Names: | MDL-1 |
| Organisms: | Caenorhabditis elegans |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q21663 |
| Description: | MAD-Like: mdl-1 encodes a basic helix-loop-helix (bHLH) protein similar to the vertebrate MAD transcriptional regulators; in vitro, MDL-1 can heterodimerize, and bind an E-box DNA sequence, with MXL-1, a C. elegans MAX-like bHLH protein; when expressed in rat embryonic fibroblasts, MDL-1 is able to suppress c-MYC/RAS-induced cell transformation, in a manner dependent upon an intact, predicted SIN3 interaction domain; mdl-1::gfp promoter fusions are expressed in a number of different tissues, including the |
| Length: | 280 |
| Pfam Domains: | 96-147 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 EQQLNLGHLLTAARLLDIGALDISSLDLGALTSTSSSPGSSSPAMFELSNESELRSLFCG 60 61 KLKVDKKQSSCASNASTSSQPYCSSPPARKSSKHSRTAHNELEKTRRANLRGCLETLKML 120 121 VPCVSDATRNTTLALLTRARDHIIELQDSNAAQMKKLNDLRDEQDELVAELAQLQADEEV 180 181 AQATSQACQTLSQSRPESRASSFTSTSSRDSPCYLEYSPSSKPMDSHKPTIIDLYAEGLI 240 241 PRGPITFPRPLVYPHNVFDLMNLPPTPFDVSQFLPINLQV |
| Interface Residues: | 98, 99, 100, 102, 103, 106, 107, 126, 129, 134, 138 |
| 3D-footprint Homologues: | 1an4_A, 5nj8_D, 7f2f_B, 4h10_A, 5v0l_A, 1am9_A, 7ssa_L, 5eyo_A, 6g1l_A, 7xi3_A, 5i50_B, 2ql2_D, 8osl_P, 6ny1_Y |
| Binding Motifs: | UP00382A_1 Awkwwtwaaaawwa UP00382A_2 twdasCACGTGskawb |
| Binding Sites: | AACACGTG ACACGTGC ACACGTGG ACCACGTG AGCACGTG ATCACGTG CACGTGAC CACGTGCA CACGTGCC CACGTGCG CACGTGGA CACGTGGC CACGTGGG CACGTGTC CCACGTGA CCACGTGC CCACGTGG GCACGTGA GCACGTGC TCACGTGA |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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