Transcription Factor
| Accessions: | ETV7 (HT-SELEX2 May2017), Q9Y603 (JASPAR 2024) |
| Names: | ENSG00000010030, ETV7, ETS translocation variant 7, ETS-related protein Tel2, ETV7_HUMAN, Tel-related Ets factor, Transcription factor ETV7, Transcription factor Tel-2 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1, JASPAR 2024 2 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | TF family: ETS experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: ETS experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 341 |
| Pfam Domains: | 47-116 Sterile alpha motif (SAM)/Pointed domain 225-306 Ets-domain |
| Sequence: (in bold interface residues) | 1 MQEGELAISPISPVAAMPPLGTHVQARCEAQINLLGEGGICKLPGRLRIQPALWSREDVL 60 61 HWLRWAEQEYSLPCTAEHGFEMNGRALCILTKDDFRHRAPSSGDVLYELLQYIKTQRRAL 120 121 VCGPFFGGIFRLKTPTQHSPVPPEEVTGPSQMDTRRGHLLQPPDPGLTSNFGHLDDPGLA 180 181 RWTPGKEESLNLCHCAELGCRTQGVCSFPAMPQAPIDGRIADCRLLWDYVYQLLLDTRYE 240 241 PYIKWEDKDAKIFRVVDPNGLARLWGNHKNRVNMTYEKMSRALRHYYKLNIIKKEPGQKL 300 301 LFRFLKTPGKMVQDKHSHLEPLESQEQDRIEFKDKRPEISP |
| Interface Residues: | 277, 278, 280, 281, 282, 284, 285, 299 |
| 3D-footprint Homologues: | 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | UN0495.1 amsCGGAMGGATdTCCGgyt UN0506.1 rsmGGAmGGAykTCCkss UN0512.1 asmGGAMGGAydTCCksb UN0524.1 rvGGAmGGATgTCCkbg MA1708.1 rgscGGAARTr UN0528.1 rsmGGAmGGAtdTCCgsb UN0584.1 rGAATGCGGAAGyrytTCCg ETV7_3 / UN0119.1 scGGAAGyrCTTCCgs ETV7_4 / UN0120.1 ryTTCCsGGAAry ETV7_methyl_1 smGGAAGyACTTCCks ETV7_methyl_2 ryTTCCsGGAArt MA1708.2 scGGAARTr UN0495.2 sCGGAMGGATdTCCGg UN0506.2 GGAmGGAykTCC UN0512.2 GGAMGGAydTCC UN0524.2 GGAmGGATgTCC UN0528.2 mGGAmGGAtdTCCg UN0584.2 rGAATGCGGAAGyrytTCC |
| Publications: | Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] |
| Related annotations: | PaperBLAST |
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