DNA Binding Motif

						

			
Accessions: ETV2_ETV7 (HumanTF2 1.0), UN0512.1 (JASPAR 2024)

			
Names: ETV2_ETV7, ETV2::ETV7
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 18
Consensus: asmGGAMGGAydTCCksb
Weblogo: 
PSSM: P0      A      C      G      T
01   2751   2060   2120   1550      a
02   2693   4601   3879   1773      s
03   3033   5447   2078    669      m
04    196      8   8480      2      G
05      5      5   8480      3      G
06   8480    133     43     11      A
07   3244   8480      0      9      M
08      3      2   8480      1      G
09      6      9   8480      6      G
10   8480      2     26     12      A
11   1032   3270     12   5210      y
12   2294     72   2613   3502      d
13    217      5     16   8480      T
14      9   8480     16      2      C
15      9   8480      8    252      C
16    644   1925   5214   3267      k
17   1868   4336   4144   2705      s
18   1496   2138   2725   2122      b
Type: Heterodimer
Binding TFs: Q9Y603 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
ETV2_TF1 (Ets-domain)
ETV7_TF1 / ETV7_TF2 (Ets-domain, Sterile alpha motif (SAM)/Pointed domain)
Q9Y603
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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