Transcription Factor
| Accessions: | UP00588A (UniPROBE 20160601) |
| Names: | ESX1_REF, ESX1L, ESX1R, ESXR1, Extraembryonic, homeobox 1, homeobox protein ESX1, spermatogenesis |
| Organisms: | Homo sapiens |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | homeobox protein ESX1: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. |
| Length: | 86 |
| Pfam Domains: | 15-71 Homeobox domain |
| Sequence: (in bold interface residues) | 1 GPQTAEGPQPPERKRRRRTAFTQFQLQELENFFDESQYPDVVARERLAARLNLTEDRVQV 60 61 WFQNRRAKWKRNQRVLMLRNTATADL |
| Interface Residues: | 15, 16, 17, 18, 20, 56, 57, 59, 60, 63, 64, 67, 68, 71 |
| 3D-footprint Homologues: | 5zfz_A, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 1fjl_B, 3d1n_M, 1nk2_P, 1zq3_P, 4j19_B, 1jgg_B, 3lnq_A, 2lkx_A, 2ld5_A, 7q3o_C, 2hos_A, 1b72_A, 4cyc_A, 6m3d_C, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 1au7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 4xrs_G, 7xrc_C, 2xsd_C, 1e3o_C, 1le8_A, 1o4x_A, 8g87_X, 1du0_A, 4qtr_D |
| Binding Motifs: | UP00588A_1 mahrgcGCTAATTAGygcswGm |
| Binding Sites: | GGTAATTA ACCAATTA ACTAATTA AGTAATTA ATAATTAG ATAATTGG ATTAATTA CCAATTAG CCTAATTA CTAATTAA CTAATTAC CTAATTAG CTTAATTA GATAATTA GCTAATTA GTAATTAA GTAATTAC GTTAATTA TAATTAGA TTAATTAA |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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