Transcription Factor
| Accessions: | MYBL1_DBD (HumanTF 1.0), MYBL1_TF1 (HumanTF2 1.0) |
| Names: | A-Myb, Myb-like protein 1, Myb-related protein A, MYBA_HUMAN, MYBL1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P10243 |
| Notes: | Ensembl ID: ENSG00000185697; DNA-binding domain sequence; TF family: MYB; Clone source: Gene synthesis, Ensembl ID: ENSG00000185697; Construct type: TF1(SBP); TF family: SANT; Clone source: Jolma et al. 2013 |
| Length: | 209 |
| Pfam Domains: | 35-81 Myb-like DNA-binding domain 38-98 Myb-like DNA-binding domain 87-133 Myb-like DNA-binding domain 90-147 Myb-like DNA-binding domain 139-183 Myb-like DNA-binding domain 142-195 Myb-like DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTL 60 61 IASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGR 120 121 IGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHW 180 181 NSTMRRKVEQEGYLQDGIKSERSSSKLQH |
| Interface Residues: | 35, 70, 71, 74, 75, 78, 79, 121, 122, 123, 124, 126, 127, 131, 132, 159, 168, 174, 177, 178, 179, 181, 186 |
| 3D-footprint Homologues: | 1w0t_A, 7xur_A, 2kdz_A, 1vfc_A, 7el3_B |
| Binding Motifs: | MYBL1_DBD_1 rCcGTTaAACbg MYBL1_DBD_2 ACCGTTAACsgy MYBL1_DBD_3 wwaACCGTTaa MYBL1_DBD_4 GrCsGTTawwaCsGTTr MYBL1_ELF1 amCCGGAACCGTTa MYBL1_EOMES_1 mcsyGacyAACsghmyycaCrCcy MYBL1_EOMES_2 rsGTGtshAACgg MYBL1_FIGLA_1 mCAssTGkkrvbgrcsGTTr MYBL1_FIGLA_2 mCAssTGgtsskyrrcsGTTr MYBL1_FIGLA_2_3 vCAssTGgyrsrdkrrcsGTyr MYBL1_FIGLA_2_3_4 mCAssTGkwvcmgyAACsGyc MYBL1_FIGLA_2_3_4_5 mCAssTGgrvksyaACsGty MYBL1_HOXA13 CTCRTAAAwwakkrmCGTTr MYBL1_MAX_1 sCACGTGcyyAACsgyy MYBL1_MAX_2 yAACskhhryvtggagCACGTG MYBL1_MAX_2_3 yAACsgymgwvgcrrrsCACGTG MYBL1_ONECUT2 yAACGgtTATyGAty MYBL1_TBX21 aGGTGTGACsGTTr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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