DNA Binding Site
| Accessions: | PF0036.1.11 (JASPAR 2024), PF0036.1.12 (JASPAR 2024), PF0036.1.13 (JASPAR 2024), PF0036.1.15 (JASPAR 2024), PF0036.1.16 (JASPAR 2024), PF0036.1.18 (JASPAR 2024), PF0036.1.2 (JASPAR 2024), PF0036.1.3 (JASPAR 2024), PF0036.1.4 (JASPAR 2024), PF0036.1.9 (JASPAR 2024), MA0031.2.11 (JASPAR 2024), MA0031.2.3 (JASPAR 2024), MA0157.4.10 (JASPAR 2024), MA0157.4.13 (JASPAR 2024), MA0157.4.15 (JASPAR 2024), MA0157.4.17 (JASPAR 2024), MA0157.4.5 (JASPAR 2024), MA0157.4.7 (JASPAR 2024), MA0480.3.10 (JASPAR 2024), MA0480.3.19 (JASPAR 2024), MA0481.4.10 (JASPAR 2024), MA0481.4.11 (JASPAR 2024), MA0481.4.16 (JASPAR 2024), MA0481.4.17 (JASPAR 2024), MA0481.4.4 (JASPAR 2024), MA0481.4.9 (JASPAR 2024), MA0852.3.10 (JASPAR 2024), MA0852.3.12 (JASPAR 2024), MA0852.3.13 (JASPAR 2024), MA0852.3.17 (JASPAR 2024), MA0852.3.18 (JASPAR 2024), MA0852.3.19 (JASPAR 2024), MA0852.3.2 (JASPAR 2024), MA0852.3.20 (JASPAR 2024), MA0852.3.4 (JASPAR 2024), MA0852.3.5 (JASPAR 2024), MA1103.3.6 (JASPAR 2024), MA1606.2.11 (JASPAR 2024), MA1606.2.15 (JASPAR 2024), MA1606.2.19 (JASPAR 2024), MA1606.2.9 (JASPAR 2024), MA1683.2.11 (JASPAR 2024), MA1683.2.12 (JASPAR 2024), MA1683.2.13 (JASPAR 2024), MA1683.2.15 (JASPAR 2024), MA1683.2.18 (JASPAR 2024), MA1683.2.19 (JASPAR 2024), MA1683.2.20 (JASPAR 2024), MA1683.2.4 (JASPAR 2024), MA2117.1.13 (JASPAR 2024), MA2117.1.14 (JASPAR 2024), MA2117.1.15 (JASPAR 2024), MA2117.1.3 (JASPAR 2024), MA2117.1.8 (JASPAR 2024), MA2117.1.9 (JASPAR 2024), UN0436.2.13 (JASPAR 2024), UN0436.2.2 (JASPAR 2024), UN0436.2.20 (JASPAR 2024), UN0436.2.7 (JASPAR 2024), UN0436.2.8 (JASPAR 2024), UN0802.1.10 (JASPAR 2024), UN0802.1.11 (JASPAR 2024), UN0802.1.2 (JASPAR 2024), UN0802.1.6 (JASPAR 2024), UN0802.1.7 (JASPAR 2024) |
| Organisms: | Homo sapiens, Mus musculus, Drosophila melanogaster |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 7 |
| Sequence: | GTAAACA |
| Type: | Heterodimer |
| Binding TFs: | Q9WVH4 (Fork head domain) P55318 (Fork head domain, Forkhead N-terminal region, HNF3 C-terminal domain) Q9R1E0 (Fork head domain) Q01167 (Fork head domain, FHA domain) Q61080 (Fork head domain) P85037 (Fork head domain, FHA domain) Q16676 (Fork head domain) Q9H334 (Fork head domain) Q86P48 Q8IVH2 (Fork head domain) P55318 P85037 Q01167 Q08050 Q16676 Q61080 Q86P48 Q8IVH2 Q9H334 Q9R1E0 Q9WVH4 |
| Binding Motifs: | PF0036.1 rTAAACA MA0031.2 GTAAACA MA0157.4 GTAAACA MA0480.3 GTAAACA MA0481.4 GTAAACA MA0852.3 GTAAACA MA1103.3 GTAAACA MA1606.2 rTAAACA MA1683.2 GTAAACA MA2117.1 GTAAACA UN0436.2 GTAAACA UN0802.1 GTAAACA |
| Publications: | Xie X, Lu J, Kulbokas E.J, Golub T.R, Mootha V, Lindblad-Toh K, Lander E.S, Kellis M. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 434:338-45 (2005). [Pubmed] Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 13:5002-5012 (1994). [Pubmed] Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] Furuyama T., Nakazawa T., Nakano I., Mori N. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349:629-634 (2000). [Pubmed] Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung H.K, Alvarez M, Talukder S, Pan Q, Mazzoni E.O, Nedelec S, Wichterle H, Woltjen K, Hughes T.R, Zandstra P.W, Nagy A, Wrana J.L, Blencowe B.J. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell 147:132-46 (2011). [Pubmed] Tsai K.L, Huang C.Y, Chang C.H, Sun Y.J, Chuang W.J, Hsiao C.D. Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. The Journal of biological chemistry 281:17400-9 (2006). [Pubmed] Chen X, Ji Z, Webber A, Sharrocks AD. Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. Nucleic Acids Res 44:1566-78 (2016). [Pubmed] Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] Motallebipour M, Ameur A, Reddy Bysani MS, Patra K, Wallerman O, Mangion J, Barker MA, McKernan KJ, Komorowski J, Wadelius C. Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. Genome Biol : (2009;10(11):R129.). [Pubmed] Li S, Weidenfeld J, Morrisey EE. Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol 24:809-22 (2004). [Pubmed] |
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