Transcription Factor
| Accessions: | Q01167 (JASPAR 2024), ForkheadK2 (EEADannot 2023-12-22) |
| Names: | Cellular transcription factor ILF-1, Forkhead box protein K2, FOXK1, FOXK2_HUMAN, G/T-mismatch specific binding protein, Interleukin enhancer-binding factor 1, nGTBP, Forkhead K2, NP_004505.2 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1, EEADannot 2023-12-22 2 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] 2 Contreras-Moreira B, Sebastian A. FootprintDB: Analysis of Plant Cis-Regulatory Elements, Transcription Factors, and Binding Interfaces. Methods Mol Biol 1482:259-77 (2016) [Pubmed] |
| Notes: | family:Forkhead |
| Length: | 660 |
| Pfam Domains: | 54-130 FHA domain 258-352 Fork head domain |
| Sequence: (in bold interface residues) | 1 MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNS 60 61 SQGSVDVSMGHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG 120 121 VFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSSEKREKQEASESPVKAVQPHIS 180 181 PLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQ 240 241 PENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADK 300 301 GWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLIEQAFRKRRPRGVPCFRT 360 361 PLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEAR 420 421 FAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAV 480 481 SVTSVAGLAPANTYTVSGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLG 540 541 TASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVPTAVHGQVNNAAASP 600 601 LHMLATHASASASLPTKRHNGDQPEQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN 660 |
| Interface Residues: | 298, 301, 303, 304, 305, 307, 308, 309, 311, 312, 321, 328, 353 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 3qrf_G |
| Binding Motifs: | MA1103.1 awgTAAACAar MA1103.2 awGTAAACAar EEAD0010 sCwTGTTTAC MA1103.3 GTAAACA |
| Binding Sites: | MA1103.3.12 / MA1103.3.16 / MA1103.3.4 MA1103.3.1 MA1103.1.1 / MA1103.2.2 / MA1103.2.4 MA1103.1.10 / MA1103.1.5 / MA1103.2.11 / MA1103.2.13 / MA1103.2.18 MA1103.1.11 MA1103.1.12 MA1103.1.13 MA1103.1.14 MA1103.1.15 MA1103.1.16 MA1103.1.17 MA1103.1.18 MA1103.1.19 MA1103.1.2 / MA1103.2.10 / MA1103.2.8 MA1103.1.20 MA1103.1.3 / MA1103.2.11 / MA1103.2.9 MA1103.1.4 / MA1103.2.10 MA1103.1.6 / MA1103.2.12 / MA1103.2.14 MA1103.1.7 / MA1103.2.13 / MA1103.2.16 MA1103.1.8 / MA1103.2.16 / MA1103.2.19 MA1103.1.9 / MA1103.2.17 / MA1103.2.20 MA1103.3.6 MA1103.2.3 / MA1103.2.5 MA1103.2.6 / MA1103.2.8 MA1103.2.1 MA1103.2.12 MA1103.2.15 MA1103.2.14 / MA1103.2.17 MA1103.2.18 MA1103.2.2 MA1103.2.1 / MA1103.2.3 MA1103.2.4 / MA1103.2.6 MA1103.2.5 / MA1103.2.7 MA1103.2.9 MA1103.2.15 MA1103.2.19 MA1103.2.20 MA1103.2.7 MA1103.3.11 / MA1103.3.13 / MA1103.3.14 / MA1103.3.18 / MA1103.3.9 MA1103.3.2 / MA1103.3.8 MA1103.3.19 MA1103.3.20 MA1103.3.7 MA1103.3.10 MA1103.3.3 / MA1103.3.5 MA1103.3.15 MA1103.3.17 |
| Publications: | Chen X, Ji Z, Webber A, Sharrocks AD. Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. Nucleic Acids Res 44:1566-78 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.