Transcription Factor
| Accessions: | Q9H334 (JASPAR 2024) |
| Names: | Forkhead box protein P1, FOXP1_HUMAN, Mac-1-regulated forkhead, MFH |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9H334 |
| Length: | 677 |
| Pfam Domains: | 465-545 Fork head domain |
| Sequence: (in bold interface residues) | 1 MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQ 60 61 ALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQV 120 121 LSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLA 180 181 FQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHT 240 241 AEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSH 300 301 PLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKE 360 361 RLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQG 420 421 PSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILE 480 481 SPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVE 540 541 FQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLAS 600 601 AIREELNGAMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPD 660 661 FDHDRDYEDEPVNEDME |
| Interface Residues: | 488, 507, 508, 510, 511, 512, 514, 515, 516, 518, 519, 528, 530, 547 |
| 3D-footprint Homologues: | 8vfz_O, 8bzm_E, 7vox_H, 2hdc_A, 7tdx_A, 2a07_J, 7yzb_A, 6el8_A, 7vou_C, 2c6y_A, 7yze_A, 7cby_C, 7yzg_A, 7tdw_A, 7yz7_A, 3g73_A, 8sro_B |
| Binding Motifs: | MA0481.1 maaadRTAAACAaAr MA0481.2 awGTAAACAgaw MA0481.3 awGTAAACAww MA0481.4 GTAAACA |
| Binding Sites: | MA0481.4.2 / MA0481.4.7 MA0481.4.1 / MA0481.4.12 / MA0481.4.13 / MA0481.4.14 MA0481.1.1 MA0481.1.10 / MA0481.1.11 / MA0481.1.12 / MA0481.1.13 / MA0481.1.8 / MA0481.1.9 MA0481.1.14 / MA0481.1.15 / MA0481.1.16 / MA0481.1.17 / MA0481.1.18 / MA0481.1.19 / MA0481.1.20 MA0481.1.2 MA0481.1.3 MA0481.1.4 MA0481.1.5 MA0481.1.6 MA0481.1.7 MA0481.2.1 MA0481.2.10 MA0481.2.11 MA0481.2.12 MA0481.2.13 MA0481.2.14 MA0481.2.15 MA0481.2.16 MA0481.2.17 MA0481.2.18 MA0481.2.19 MA0481.2.2 MA0481.2.20 MA0481.2.3 MA0481.2.4 MA0481.2.5 MA0481.2.6 MA0481.2.7 MA0481.2.8 MA0481.2.9 MA0481.3.18 MA0481.3.15 MA0481.4.10 / MA0481.4.11 / MA0481.4.16 / MA0481.4.17 / MA0481.4.4 / MA0481.4.9 MA0481.3.6 / MA0481.3.8 MA0481.3.1 MA0481.3.10 MA0481.3.11 MA0481.3.12 MA0481.3.13 MA0481.3.14 MA0481.3.16 MA0481.3.17 MA0481.3.19 MA0481.3.2 / MA0481.3.3 MA0481.3.19 / MA0481.3.20 MA0481.3.3 / MA0481.3.4 MA0481.3.4 / MA0481.3.5 MA0481.3.5 MA0481.3.7 / MA0481.3.9 MA0481.3.10 / MA0481.3.8 MA0481.3.11 / MA0481.3.9 MA0481.3.2 MA0481.3.20 MA0481.3.6 MA0481.3.7 MA0481.4.18 / MA0481.4.3 MA0481.4.20 MA0481.4.15 MA0481.4.19 / MA0481.4.5 MA0481.4.6 MA0481.4.8 |
| Publications: | Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O'Hanlon D, Sung H.K, Alvarez M, Talukder S, Pan Q, Mazzoni E.O, Nedelec S, Wichterle H, Woltjen K, Hughes T.R, Zandstra P.W, Nagy A, Wrana J.L, Blencowe B.J. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell 147:132-46 (2011). [Pubmed] |
| Related annotations: | PaperBLAST |
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