Transcription Factor
| Accessions: | P85037 (JASPAR 2024) |
| Names: | Forkhead box protein K1, FOXK1_HUMAN, MNF, Myocyte nuclear factor |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P85037 |
| Length: | 733 |
| Pfam Domains: | 123-192 FHA domain 305-400 Fork head domain |
| Sequence: (in bold interface residues) | 1 MAEVGEDSGARALLALRSAPCSPVLCAAAAAAAFPAAAPPPAPAQPQPPPGPPPPPPPPL 60 61 PPGAIAGAGSSGGSSGVSGDSAVAGAAPALVAAAAASVRQSPGPALARLEGREFEFLMRQ 120 121 PSVTIGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAP 180 181 ALQLPKQCTFRFPSTAIKIQFTSLYHKEEAPASPLRPLYPQISPLKIHIPEPDLRSMVSP 240 241 VPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDLQLAAEFAAKAASEQQADTSGGDSP 300 301 KDESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLN 360 361 RYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRSAPAS 420 421 PTHPGLMSPRSGGLQTPECLSREGSPIPHDPEFGSKLASVPEYRYSQSAPGSPVSAQPVI 480 481 MAVPPRPSSLVAKPVAYMPASIVTSQQPAGHAIHVVQQAPTVTMVRVVTTSANSANGYIL 540 541 TSQGAAGGSHDAAGAAVLDLGSEARGLEEKPTIAFATIPAAGGVIQTVASQMAPGVPGHT 600 601 VTILQPATPVTLGQHHLPVRAVTQNGKHAVPTNSLAGNAYALTSPLQLLATQASSSAPVV 660 661 VTRVCEVGPKEPAAAVAATATTTPATATTASASASSTGEPEVKRSRVEEPSGAVTTPAGV 720 721 IAAAGPQGPGTGE |
| Interface Residues: | 345, 348, 350, 351, 352, 354, 355, 356, 358, 359, 368, 375, 400 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 3qrf_G |
| Binding Motifs: | MA0852.2 wrkGTAAACAagsv MA0852.3 GTAAACA |
| Binding Sites: | MA0852.3.16 MA0852.2.1 MA0852.2.10 MA0852.2.11 MA0852.2.12 MA0852.2.13 MA0852.2.14 MA0852.2.15 MA0852.2.16 MA0852.2.17 MA0852.2.18 MA0852.2.19 MA0852.2.2 MA0852.2.20 MA0852.2.3 MA0852.2.4 MA0852.2.5 MA0852.2.6 MA0852.2.7 MA0852.2.8 MA0852.2.9 MA0852.3.10 / MA0852.3.12 / MA0852.3.13 / MA0852.3.17 / MA0852.3.18 / MA0852.3.19 / MA0852.3.2 / MA0852.3.20 / MA0852.3.4 / MA0852.3.5 MA0852.3.11 / MA0852.3.15 / MA0852.3.7 / MA0852.3.9 MA0852.3.3 MA0852.3.1 MA0852.3.6 MA0852.3.14 MA0852.3.8 |
| Publications: | Tsai K.L, Huang C.Y, Chang C.H, Sun Y.J, Chuang W.J, Hsiao C.D. Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. The Journal of biological chemistry 281:17400-9 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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