Transcription Factor
| Accessions: | T081997_1.02 (CISBP 1.02), FOXO3_MOUSE (HOCOMOCO 10), Q9WVH4 (JASPAR 2024) |
| Names: | Foxo3, T081997_1.02;, FOXO3_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Forkhead |
| Length: | 672 |
| Pfam Domains: | 159-240 Fork head domain |
| Sequence: (in bold interface residues) | 1 MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE 60 61 DDDEDDEDGGGRASSAMVIGGGVSSTLGSGLLLEDSAMLLAPGGQDLGSGPASAAGALSG 120 121 GTPTQLQPQQPLPQPQPGAAGGSGQPRKCSSRRNAWGNLSYADLITRAIESSPDKRLTLS 180 181 QIYEWMVRCVPYFKDKGDSNSSAGWKNSIRHNLSLHSRFMRVQNEGTGKSSWWIINPDGG 240 241 KSGKAPRRRAVSMDNSNKYTKSRGRAAKKKAALQAAPESADDSPSQLSKWPGSPTSRSSD 300 301 ELDAWTDFRSRTNSNASTVSGRLSPILASTELDDVQDDDGPLSPMLYSSSASLSPSVSKP 360 361 CTVELPRLTDMAGTMNLNDGLAENLMDDLLDNIALPPSQPSPPGGLMQRGSSFPYTAKSS 420 421 GLGSPTGSFNSTVFGPSSLNSLRQSPMQTIQENRPATFSSVSHYGNQTLQDLLASDSLSH 480 481 SDVMMTQSDPLMSQASTAVSAQNARRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQ 540 541 GALGGSRALSNSVSNMGLSDSSSLGSAKHQQQSPASQSMQTLSDSLSGSSLYSASANLPV 600 601 MGHDKFPSDLDLDMFNGSLECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTG 660 661 AKQASSQSWVPG |
| Interface Residues: | 201, 204, 206, 207, 208, 210, 211, 212, 214, 215, 224, 229, 248 |
| 3D-footprint Homologues: | 3l2c_A, 7vox_H, 2hdc_A, 7yz7_A, 6el8_A, 7tdx_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 3qrf_G |
| Binding Motifs: | M0733_1.02 rTmAACAa FOXO3_MOUSE.H10MO.B|M01109 krytTGTTTwcmt MA0157.3 wwGTAAACAara MA0157.4 GTAAACA |
| Binding Sites: | MA0157.4.19 MA0157.4.18 / MA0157.4.3 MA0157.4.1 MA0157.4.10 / MA0157.4.13 / MA0157.4.15 / MA0157.4.17 / MA0157.4.5 / MA0157.4.7 MA0157.3.1 / MA0157.3.2 MA0157.3.10 / MA0157.3.17 MA0157.3.11 / MA0157.3.18 MA0157.3.12 / MA0157.3.19 MA0157.3.13 / MA0157.3.20 MA0157.3.14 MA0157.3.15 MA0157.3.16 MA0157.3.17 MA0157.3.18 MA0157.3.19 MA0157.3.2 / MA0157.3.3 MA0157.3.20 MA0157.3.3 / MA0157.3.7 MA0157.3.10 / MA0157.3.4 MA0157.3.11 / MA0157.3.5 MA0157.3.12 / MA0157.3.6 MA0157.3.13 / MA0157.3.7 MA0157.3.15 / MA0157.3.8 MA0157.3.16 / MA0157.3.9 MA0157.3.1 MA0157.3.14 MA0157.3.4 MA0157.3.5 MA0157.3.6 MA0157.3.8 MA0157.3.9 MA0157.4.11 / MA0157.4.14 MA0157.4.12 MA0157.4.16 / MA0157.4.2 / MA0157.4.6 MA0157.4.20 MA0157.4.4 MA0157.4.8 MA0157.4.9 |
| Publications: | Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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