DNA Binding Motif

						

			
Accessions: UP00604E_1 (UniPROBE 20160601)

			
Names: Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, Homeobox protein CSX, Homeobox protein NK-2 homolog E, homeobox protein Nkx-2.5, NKX2-5_T178M_R1, NKX2.5, NKX2E, NKX4-1
Organisms: Homo sapiens
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Length: 22
Consensus: tawwywATrTwwATtAwytaAA
Weblogo: 
PSSM: P0      A      C      G      T
01   0.09   0.23   0.05   0.63      t
02   0.61   0.15   0.07   0.17      a
03   0.66   0.03   0.05   0.26      w
04   0.56   0.10   0.05   0.28      w
05   0.09   0.62   0.04   0.26      y
06   0.38   0.20   0.10   0.32      w
07   0.75   0.06   0.09   0.10      A
08   0.10   0.05   0.04   0.81      T
09   0.46   0.08   0.25   0.21      r
10   0.07   0.10   0.03   0.80      T
11   0.65   0.03   0.07   0.26      w
12   0.44   0.13   0.15   0.27      w
13   0.83   0.03   0.04   0.11      A
14   0.11   0.03   0.04   0.83      T
15   0.25   0.03   0.05   0.68      t
16   0.79   0.08   0.07   0.06      A
17   0.26   0.25   0.17   0.33      w
18   0.12   0.56   0.07   0.25      y
19   0.18   0.13   0.07   0.61      t
20   0.64   0.11   0.03   0.22      a
21   0.72   0.07   0.15   0.06      A
22   0.79   0.06   0.11   0.04      A
Binding TFs: UP00604E (Homeobox domain)
Binding Sites: ATTATAAT
AAATATAT
AATATATT
AATTAATA
ATAAAATA
ATAAATAA
ATAATTAC
ATAATTAT
ATATAAAT
ATTAAATA
ATTATTTA
TAATTATA
TATAAACA
AAATTATC
AATAAATA
AATTATAA
ACATATTA
ATATAACA
ATTAACAA
TATAATAA
			
Publications: Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.