Transcription Factor
| Accessions: | UP00170A (UniPROBE 20160601) |
| Names: | Insulin gene enhancer protein ISL-2, insulin related protein 2 (islet 2), Isl2, islet-2 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q9CXV0 |
| Description: | insulin related protein 2 (islet 2) |
| Length: | 93 |
| Pfam Domains: | 18-73 Homeobox domain 38-68 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 RQPSLRTHVDKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVI 60 61 RVWFQNKRCKDKKKSILMKQLQQQQHSDKASFQ |
| Interface Residues: | 6, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 1puf_B, 3d1n_M, 3lnq_A, 2lkx_A, 1jgg_B, 6m3d_C, 2h1k_B, 5hod_A, 6a8r_A, 3cmy_A, 2hdd_A, 3rkq_B, 4xrs_G, 2hos_A, 1fjl_B, 5zfz_A, 2d5v_B, 1b72_A, 5flv_I, 3l1p_A, 5jlw_D, 2ld5_A, 1ig7_A, 7q3o_C, 1e3o_C, 1au7_A, 7xrc_C, 2xsd_C, 1le8_A, 5zjt_E, 4qtr_D, 3a01_E, 1mnm_C, 7psx_B, 1du0_A, 4xrm_B, 1nk2_P, 2r5y_A, 1zq3_P, 1k61_B, 6es3_K, 1o4x_A, 4cyc_A, 1puf_A, 8g87_X |
| Binding Motifs: | UP00170A_1 mhmaAyymMTTAakwy |
| Binding Sites: | AATTAATG ACCACTTA ACTAATGG ACTAATTA ATAATTAA ATCAATTA ATCCATTA ATTAATTA CATTAATG CCATTAAC CCATTAGC CTAATGGA CTAATTAA CTAATTAG GTCCATTA GTTAATTA TAATGGAA TCAATTAA TCCATTAA TTAATTAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.