Transcription Factor
| Accessions: | UP00464A (UniPROBE 20160601), Q02100 (JASPAR 2024) |
| Names: | ACR1, Sko1, Suppressor of Kinase Overexpression, SKO1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | UniPROBE 20160601 1, JASPAR 2024 2 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Suppressor of Kinase Overexpression : Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses |
| Length: | 647 |
| Pfam Domains: | 14-30 Aft1 osmotic stress response (OSM) domain 427-478 bZIP transcription factor 433-473 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MSSEERSRQPSTVSTFDLEPNPFEQSFASSKKALSLPGTISHPSLPKELSRNNSTSTITQ 60 61 HSQRSTHSLNSIPEENGNSTVTDNSNHNDVKKDSPSFLPGQQRPTIISPPILTPGGSKRL 120 121 PPLLLSPSILYQANSTTNPSQNSHSVSVSNSNPSAIGVSSTSGSLYPNSSSPSGTSLIRQ 180 181 PRNSNVTTSNSGNGFPTNDSQMPGFLLNLSKSGLTPNESNIRTGLTPGILTQSYNYPVLP 240 241 SINKNTITGSKNVNKSVTVNGSIENHPHVNIMHPTVNGTPLTPGLSSLLNLPSTGVLANP 300 301 VFKSTPTTNTTDGTVNNSISNSNFSPNTSTKAAVKMDNPAEFNAIEHSAHNHKENENLTT 360 361 QIENNDQFNNKTRKRKRRMSSTSSTSKASRKNSISRKNSAVTTAPAQKDDVENNKISNNV 420 421 TLDENEEQERKRKEFLERNRVAASKFRKRKKEYIKKIENDLQFYESEYDDLTQVIGKLCG 480 481 IIPSSSSNSQFNVNVSTPSSSSPPSTSLIALLESSISRSDYSSAMSVLSNMKQLICETNF 540 541 YRRGGKNPRDDMDGQEDSFNKDTNVVKSENAGYPSVNSRPIILDKKYSLNSGANISKSNT 600 601 TTNNVGNSAQNIINSCYSVTNPLVINANSDTHDTNKHDVLSTLPHNN |
| Interface Residues: | 432, 435, 438, 439, 440, 442, 443, 446, 447 |
| 3D-footprint Homologues: | 1gd2_G, 2wt7_A, 5t01_B, 1dh3_C, 5vpe_D, 7x5e_F |
| Binding Motifs: | MA0382.1 ACGTAwTG UP00464A_1 / UP00464A_2 mhhkmmgATGACGTAwkmrrtt UP00464A_3 TGACGTCA MA0382.2 wwyrATGACGTMAttkw MA0382.3 ATGACGTMAt |
| Binding Sites: | CTACGTCA TGACGTAA TGACGTCA AACGTCAT AATGACGT ACGTAATA ACGTAATC ACGTCATA ACGTCATC ACGTCATG ATGACGCA ATGACGTA ATGACGTC ATGACGTG ATTACGTA GTGACGTA TTACGTAA AATTACGT ATACGTCA ATTACGTC MA0382.2.1 MA0382.2.10 / MA0382.2.13 MA0382.2.11 / MA0382.2.14 MA0382.2.12 / MA0382.2.15 MA0382.2.13 / MA0382.2.16 MA0382.2.14 / MA0382.2.17 MA0382.2.15 / MA0382.2.18 MA0382.2.16 / MA0382.2.20 MA0382.2.17 MA0382.2.18 MA0382.2.19 MA0382.2.2 MA0382.2.20 MA0382.2.3 / MA0382.2.4 MA0382.2.4 / MA0382.2.5 MA0382.2.5 / MA0382.2.6 MA0382.2.6 / MA0382.2.8 MA0382.2.7 / MA0382.2.9 MA0382.2.10 / MA0382.2.8 MA0382.2.12 / MA0382.2.9 MA0382.3.13 / MA0382.3.14 / MA0382.3.4 / MA0382.3.5 MA0382.2.11 MA0382.2.19 MA0382.2.3 MA0382.2.7 MA0382.3.1 MA0382.3.10 / MA0382.3.9 MA0382.3.11 MA0382.3.12 MA0382.3.15 / MA0382.3.3 MA0382.3.16 MA0382.3.17 MA0382.3.18 MA0382.3.19 MA0382.3.2 MA0382.3.20 MA0382.3.6 MA0382.3.7 MA0382.3.8 |
| Publications: | Gordân R, Murphy KF, McCord RP, Zhu C, Vedenko A, Bulyk ML. Curated collection of yeast transcription factor DNA binding specificity data reveals novel structural and gene regulatory insights. Genome Biol : (2011). [Pubmed] Pachkov M, Erb I, Molina N, van Nimwegen E. SwissRegulon: a database of genome-wide annotations of regulatory sites. Nucleic acids research 35:D127-31 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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