Transcription Factor
| Accessions: | HOXC10_DBD (HumanTF 1.0), HOXC10_TF1 (HumanTF2 1.0), HOXC10 (HT-SELEX2 May2017) |
| Names: | Homeobox protein Hox-3I, Homeobox protein Hox-C10, HOXC10, HXC10_HUMAN, cDNA, FLJ94360, Homo sapiens homeo box C10 (HOXC10, Homeo box C10, Homeobox C10, isoform CRA_a, Q53XI4_HUMAN, ENSG00000180818 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q9NYD6 |
| Notes: | Ensembl ID: ENSG00000180818; DNA-binding domain sequence; TF family: homeodomain; Clone source: MGC, Ensembl ID: ENSG00000180818; Construct type: TF1(SBP); TF family: Homeodomain-Posterior; Clone source: Jolma et al. 2013, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 116 |
| Pfam Domains: | 43-99 Homeobox domain |
| Sequence: (in bold interface residues) | 1 PSESEKERAKAADSSPDTSDNEAKEEIKAENTTGNWLTAKSGRKKRCPYTKHQTLELEKE 60 61 FLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRELTSNFNFT |
| Interface Residues: | 43, 44, 45, 46, 84, 85, 87, 88, 91, 92, 95, 96, 99 |
| 3D-footprint Homologues: | 6m3d_C, 3cmy_A, 1fjl_B, 3d1n_M, 6a8r_A, 1ig7_A, 2h1k_B, 5zfz_A, 1puf_A, 1nk2_P, 1zq3_P, 3lnq_A, 2lkx_A, 7q3o_C, 2ld5_A, 6es3_K, 5flv_I, 2hdd_A, 5zjt_E, 2r5y_A, 1puf_B, 7psx_B, 2hos_A, 1b72_A, 5jlw_D, 4xrs_G, 3a01_E, 1jgg_B, 3rkq_B, 1e3o_C, 1le8_A, 1au7_A, 2xsd_C, 7xrc_C, 8g87_X, 4cyc_A, 5hod_A, 4qtr_D, 1o4x_A, 1du0_A |
| Binding Motifs: | HOXC10_DBD_1 scmATwAAam HOXC10_DBD_2 gymATwAAaw HOXC10_DBD_3 rTCrTwAAaw HOXC10_EOMES TmaCACcTCrTaAa HOXC10_TBX21 TmrCACyTmATWAA HOXC10_3 srTCGTAAAay HOXC10_4 gGymATAAAac HOXC10_7 grTCGTAAAay HOXC10_8 gGymATAAAAy HOXC10_methyl_1 sRTCGTAAAay HOXC10_methyl_2 gGymATAAAAc HOXC10_methyl_5 sGTCGTAAAay HOXC10_methyl_6 rGymATAAAAc |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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