DNA Binding Motif

						

			
Accessions: HOXC10_TBX21 (HumanTF2 1.0), UN0566.1 (JASPAR 2024)

			
Names: HOXC10_TBX21, HOXC10::TBX21
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1, JASPAR 2024 2
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX, HT-SELEX
Length: 14
Consensus: TmrCACyTmATWAA
Weblogo: 
PSSM: P0      A      C      G      T
01     25     78     20    686      T
02    391    294     21     43      m
03    400     11    286     55      r
04      0    686      0      0      C
05    686     14    177      8      A
06    123    686     17     10      C
07    116    398     86    288      y
08     12    136      7    686      T
09    254    432     58      0      m
10    686      0     69     42      A
11      8      5     28    686      T
12    493      2      0    192      W
13    686      0      0     27      A
14    686     61      1     74      A
Type: Heterodimer
Binding TFs: HOXC10_TF1 (Homeobox domain)
TBX21_TF2 (T-box)
Q9UL17 (T-box)
Q9UL17
			
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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