Transcription Factor

						

			
Accessions: Esrra_DBD (HumanTF 1.0), UP00079A (UniPROBE 20160601)

			
Names: ERR-alpha, ERR1_MOUSE, Esrra, Estrogen receptor-like 1, Estrogen-related receptor alpha, Nuclear receptor subfamily 3 group B member 1, Steroid hormone receptor ERR1, alpha, Err1, ERRalpha, estrogen related receptor, Estrogen-related receptor, Estrra, Nr3b1
Organisms: Mus musculus
Libraries: HumanTF 1.0 1, UniPROBE 20160601 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: O08580
Description: estrogen related receptor, alpha: Mus musculus estrogen related receptor, alpha (Esrra), mRNA.
Notes: Ensembl ID: ENSMUSG00000024955; DNA-binding domain sequence; TF family: Nuclear_Receptor; Clone source: Hughes lab.
Length: 100
Pfam Domains:     17-85 Zinc finger, C4 type (two domains)
Sequence: 
(in bold interface residues)		   1 GEQGSGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNEC   60
  61 EITKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKY
Interface Residues: 26, 27, 29, 30, 36, 37, 39, 40, 43, 44, 68, 90, 92, 94, 97
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A
Binding Motifs: UP00079A_1 kmkyCAAGGTCAtrykm
Esrra_DBD_1 dAGGTyAkTCAAGGTCA
Esrra_DBD_2 tTCAAGGTCAT
UP00079A_2 vkbkAGGGGTCAarssm
Binding Sites: AAAGGTCA
AAGGTCAA
AAGGTCAC
AAGGTCAG
AAGGTCAT
AAGGTCGT
AATGACCT
ACAAGGTC
AGAGGTCA
AGGTCAAA
AGGTCATC
CAAGGGCA
CAAGGTCG
CAAGGTTA
CCAAGGTC
GAAGGTCA
GACCTTGA
GAGGTCAA
TAAGGTCA
CAATGTCA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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