Transcription Factor

Accessions: UP00176A (UniPROBE 20160601)
Names: cone-rod homeobox containing gene, Cone-rod homeobox protein, Crx
Organisms: Mus musculus
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: O54751
Description: cone-rod homeobox containing gene
Length: 93
Pfam Domains: 17-73 Homeobox domain
Sequence:
(in bold interface residues)
1 DLMHQAVPYSSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRV 60
61 QVWFKNRRAKCRQQRQQQKQQQQPPGAQTKARP
Interface Residues: 16, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73, 77
3D-footprint Homologues: 4j19_B, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 5zfz_A, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 7q3o_C, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 6m3d_C, 1b72_A, 5flv_I, 3l1p_A, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1k61_B
Binding Motifs: UP00176A_1 ykwwGsGGATTArCck
Binding Sites: ACTAATCC
AGGATTAA
AGGGATTA
ATAATCCC
ATAATCCG
ATTAATCC
CCGGATTA
CGGATTAA
CGGATTAG
CTAATCCC
CTTAATCC
GAGGATTA
GATTAATC
GCGGATTA
GCTAATCC
GGATTAAA
GGATTAAC
GGATTATA
GGGATTAA
GGGGATTA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.