DNA Binding Site
| Accessions: | 1bc8_A (3D-footprint 20231221), 4uno_B (3D-footprint 20231221), 4uuv_T (3D-footprint 20231221), 5ybd_B (3D-footprint 20231221), MA0761.3.20 (JASPAR 2024), MA2332.1.6 (JASPAR 2024) |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1, JASPAR 2024 2 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 9 |
| Sequence: | ACCGGAAGT |
| Type: | Heterodimer |
| Binding TFs: | 1bc8_C (Ets-domain) 4uuv_S (Ets-domain) 4uuv_V (Ets-domain) 4uno_A (Ets-domain) P50549 (Ets-domain, PEA3 subfamily ETS-domain transcription factor N terminal domain) 5ybd_A (Ets-domain) P50549 Q9Y473 |
| Binding Motifs: | 5ybd_A tTCCg 1bc8_C CGGAa 4uno_A CGGa 4uuv_S ctTCCG 4uuv_SV CGGAAnTnnnCGGAnG MA0761.3 aCAGGAAGT MA2332.1 aCAGGAAGT |
| Publications: | Mo Y., Vaessen B., Johnston K., Marmorstein R. Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.. Mol. Cell 2:201-212 (1998). [Pubmed] Cooper C.D, Newman J.A, Aitkenhead H, Allerston C.K, Gileadi O. Structures of the Ets Domains of Transcription Factors ETV1, ETV4, ETV5 and FEV: Determinants of DNA Binding and Redox Regulation by Disulfide bond formation. The Journal of biological chemistry : (2015). [Pubmed] Sharma R, Gangwar SP, Saxena AK. Comparative structure analysis of the ETSi domain of ERG3 and its complex with the E74 promoter DNA sequence. Acta Crystallogr F Struct Biol Commun : (2018). [Pubmed] Schmitges FW, Radovani E, Najafabadi HS, Barazandeh M, Campitelli LF, Yin Y, Jolma A, Zhong G, Guo H, Kanagalingam T, Dai WF, Taipale J, Emili A, Greenblatt JF, Hughes TR. Multiparameter functional diversity of human C2H2 zinc finger proteins. Genome Res 26:1742-1752 (2016). [Pubmed] |
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